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Prolia (Denosumab): My Review


This past June 1st, the FDA approved Prolia ™ (denosumab), a brand new twice-yearly injectable osteoporosis drug by Amgen.

The first drug of its kind, Prolia was designed to treat and prevent postmenopausal osteoporosis for patients considered to be at high risk of fractures. It’s also marketed as an alternative treatment for those who have failed or are intolerant to other osteoporosis drugs.

Is this a time to celebrate, or is Prolia destined to end up in the osteoporosis “Hall of Shame”, along with the rest of Big Pharma’s Superstar osteoporosis drugs? I’ll let you decide, but first, let’s unravel the mysterious and tightly-woven cocoon wrapped around this novel drug.

An Old and Flawed Concept Disguised as Sci-Fi Technology

As if straight out of a sci-fi movie, the Space Agency NASA was involved in several studies related to Prolia. Here’s the scoop: in 2001, Ted Bateman, Ph.D. from Clemson University in South Carolina and Paul Kostenuik, a researcher for Amgen, teamed up to “…use the microgravity environment for evaluation of new pharmaceutical candidates (denosumab) in small mammals. Results may expedite the review of new pharmaceuticals.”1

They conducted studies on 24 female mice that spent 12 days on the International Space Station shuttle flight STS-108. Study findings confirmed that Prolia did prevent increased bone loss and maintained bone mineralization. So there you have it. The medical establishment is more than willing to send mice to space – but would they consider a natural, safe, and easy treatment? Out of the question!

On the surface, Prolia seems to be a breakthrough and fairly innocuous drug. But is it? As the first fully human monoclonal (laboratory-made) antibody and RANK Ligand inhibitor to be approved as a drug, it certainly sounds very complicated. But it really isn’t. Bear with me… I’ll explain.

Antibodies are proteins produced to neutralize “invaders”, such as bacteria and viruses. RANK Ligand (RANKL for short) is a protein that activates osteoclasts and is involved in immune-response regulation.2 As I explain in the Save Our Bones Program, osteoclasts are bone cells that remove old bone by a process called resorption. They make space so that new bone is deposited by osteoblasts, thus replacing old bone. These two processes are known as bone remodeling, the natural way by which bones renew themselves and stay strong, healthy, and more resistant to fracture.

Prolia: Same as Bisphophonates… Only Different

Now back to Prolia. The natural inhibitor of RANKL is osteoprotegerin, a tumor necrosis factor (TNF) cytokine that binds to RANKL, preventing interaction with its receptor-activator RANK on the surface of osteoblasts.3 Cytokines are chemical messengers that help regulate the nature and intensity of an immune response. Remember this for later, because it all ties in together.

So, in plain English, Prolia mimics osteoprotegerin by blocking the effects of RANKL and de-activating osteoclasts. Say “hello” to stalled bone resorption and “good-bye” to new bone deposition. But wait a minute, doesn’t this sound eerily familiar? It should, because bisphosphonates achieve the same end result as Prolia, only through a different biochemical pathway.

At the end of the day, both drugs alter normal bone metabolism, not without potential long-term nefarious consequences. For example, sudden femoral fractures are linked to long-term bisphosphonate therapy, which can be attributed to the lack of bone remodeling. Add to this formula a dose of immune system tampering, and you’ve got yourself a fully assembled health Molotov cocktail.

Studies and Stats

Amgen’s own Press Release states that “Treatment with Prolia resulted in greater bone density, stronger bones, and reduced risk for vertebral, hip and non-vertebral fractures measured at three years.”4 It backs up this statement with a study by Cummings et al. published by the New England Journal of Medicine in 2009, titled “Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis”.

And the same Press Release boasts their pivotal three year Fracture REduction Evaluation of Denosumab in Osteoporosis every six Months or “FREEDOM” study (no, this is not a bad joke) with these results:

– 4.8 percent absolute risk reduction of vertebral fractures
- 0.3 percent absolute risk reduction of hip fractures
- 1.5 percent absolute risk reduction of non-vertebral fractures 
- 8.8 percent bone density increase at the lumbar spine, 6.4 percent at the total hip, and 5.2 percent at the femoral neck.

So far, so good, especially for those who don’t mind being “guinea pigs” in exchange for short-term rewards. Because the biggest cause for concern with Prolia is its potential side-effects.

A Wolf in Sheep’s Clothing

Even though Prolia doesn’t accumulate in the body and has no known esophageal side effects as is the case with bisphosphonates, it boasts a rather long list of undesirable – and sometimes dangerous – potential side effects. In its shadow, bisphosphonates almost seem to be the lesser of both evils, and that’s no small feat. You’ll soon know why.

The most common side effects of Prolia are back pain, arm and leg aches, elevated cholesterol, general musculoskeletal pain, bladder infection, and pancreatitis.5

And as disclosed on the Prolia website (, it can cause serious side effects because it “is a medicine that may affect your immune system” (remember the cytokines?).

These are the main side effects listed by Amgen:

  • Low calcium levels
  • Serious skin, lower abdomen, bladder, or ear infections
  • Dermatitis, rash, or eczema
  • Inflammation of the inner lining of the heart (endocarditis) caused by an infection
  • Severe jaw bone problems such as osteonecrosis of the jaw.

And for dessert, Amgen serves up a cautionary statement: that “it is not known if the use of Prolia over a long period of time may cause slow healing of broken bones or unusual fractures.”

So it looks as though…

The More Things Change, the More they Stay the Same

Like bisphosphonates, Prolia opens the door to a wide array of opportunistic health problems, many of which can (and trust me, will) get covered over with yet more drugs.

And let’s not forget that this drug interferes with the body’s natural immune system, which is the obvious reason for many of its most dreaded side-effects. In fact, roughly one year before its approval, FDA reviewers expressed concerns over Prolia’s activity against an important immune system modulator.6

But evidently, those concerns were shoved to the side and quickly forgotten. It seems as though the medical establishment considers drug side-effects – no matter how terrifying – an unfortunate “numbers game”. Applying its skewed logic, it accepts that there will always be some unlucky patients that will get stuck with irreversible damage, such as osteonecrosis or endocarditis – the latter potentially resulting in heart valve destruction or even a stroke.7 The unsuspecting victims are written off as inevitable casualties of war, losing their battle, but helping win the war against “disease”.

Don’t Get Fooled by Confusing Double-Speak

It almost seems as though well-meaning scientists focus so disproportionately on solving bone health issues using hi-tech tools, that they lose sight of the risk vs. reward ratio. That’s why together at Save Our Bones, we expose the truth and dispel misconceptions, especially as they relate to brand new drugs.

Let’s face it: two injections a year may sound like an appealing solution to finally conquer osteoporosis. But the bad news is the potential high price to pay. So I urge you to consider your acceptable options and weigh the consequences of your decision. Also, please share this review with anyone you think may benefit from it.

And ALWAYS remember the good news: the Save Our Bones community is here for you and your bone health, with proven natural bone health strategies that work with your body… not against it.


1 Commercial Biomedical Testing Module: Effects of Osteoprotegerin on Bone Maintenance in Microgravity (CBTM).].
2 Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ . Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93:165–176. 1998.
3 Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Yano K, Morinaga T, Higashio K. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochemical and Biophysical Research Communications. 253:395–400. 1998.

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349 comments. Leave Yours Now →

  1. Carole March 16, 2015, 9:27 am

    How can I get statistics on the likelihood of having a bone fracture (female, aged 69)? It seems to me that should enter into a decision on taking medication?
    Are there statistics on whether the risk increases when you stop using an osteoporosis drug?

  2. Katy February 20, 2015, 4:22 pm

    I went through early menopause at the age of 38 and was diagnosed with osteoporosis at 42. I am now 58 and have been taking Evista safely (touch wood) for the past 16 years. I have recently had a Dexa scan and my results showed that the osteoporosis has retreated and is now osteopenia. Although I try to eat healthy and exercise, the drug has certainly helped. This may be a consideration to someone.

  3. Britney Alis December 26, 2014, 10:35 pm

    My battle with Breast cancer started 2 years ago, after so many Chemo, Radiation and other natural therapy treatment that i took just to cure my Breast cancer, it all did not work for my condition. I have been treating this disease for the past 2 years, but today i am here telling the world about my final victory over Breast cancer with the help of cannabis oil medication. This is a breakthrough in my family with so much Joy in our life today, i do really appreciate all the help and contribution from every member of my family for all they did for me. And if you have any kind of cancer diseases, there is no need to waste money on Chemo or Radiation, go get cannabis oil from Rick Simpson ( ) this is a medication that totally kill cancer cells.

  4. john russell November 11, 2014, 3:05 pm

    my partner died on 20th oct this year after reading some of the coments I think her doctor and hospital have made a big mistake in giving her 3 injections of prolia from july last year she had all the simptums cold sore hands and legs and needing the toilet all time sometimes doin it in bed through the night,,she died in her mortem inconclusive so its 4-6 week wait for blood tests,,,,,

    • Lisa December 5, 2014, 8:41 pm

      My mother, my twin sister and myself all have osteoporosis. My mother was advised to go on prolea by her doctor as her osteoporosis is bad. I had done a lot of research and felt that this drug was not the best for my mother. Against my research and suggestions my mother had the first injection in the spring and her second a month ago. She has numerous medical issues and recently was diagnosed with stage four breast cancer and bone cancer in her back. She had a very aggressive breast cancer about four years ago and it has came back. Now my sisters feel the Prolea has something to do with her new cancer. I really don’t know. Personally I wouldn’t go on the drug but what to you do when your osteoporosis is so bad. As for me I had a recent bone density test and within a year my bone density improved. My doctor had recommended Fortero. I did my research on this drug and no, no, no, I was not going to take this drug. It was taken off of research after two years due to cancer in laboratory mice. There is a FDA black box warning on this drug. Why would a doctor recommend this drug with these findings? What I have done in the last year was buy a weight vest and wear it as much as I can, I am taking liquid coral calcium from a company called Genius Pure, I take my calcium and D3 and my diet has improved to include natural foods. Also my husband and I installed a Reverse Osmosis water filer on our kitchen sink and we drink pure water. I believe you can improve your bone density the natural way but it takes a lot of work. But then us women are worth it. I also pray and depend on my Lord and Savior, Jesus. He is my true Physician. God Bless everyone.

  5. evie October 28, 2014, 8:52 am

    I have had shots now for 3 months…how do I get it out of my system?

  6. Kathi October 27, 2014, 7:10 am

    I have had osteoporosis for a number of years now and could not tolerate Fosamax or Actonel as caused esophagus issues. I’m scheduled for a Prolia injection tomorrow, Tuesday October 28, 2014. After reading over the number of side effects common and serious, I’m seriously backing away from getting this. Can anyone recommend another type of med like the Boniva i.v. solution or Reclast? I had read that either one of these would be better. I need some answers fast. I am going to cancel this appointment until I have some better answers in the direction I need to go. The thought of having my immune system compromised with Prolia scares me… Thanks.

    • Vivian Goldschmidt, MA October 27, 2014, 9:00 am

      Good for you, Kathi – you’re doing your research before taking the drug! You’re miles ahead of the majority. :) I encourage you to research the other osteoporosis drug options – you will find information on all of them at this site. Type the drug name into the Search box and you’ll find a wealth of information! The bottom line is, your bones don’t need drugs to thrive and improve. :)

      • Kathi October 27, 2014, 9:33 am

        Instead of Prolia I’m leaning towards Boniva iv solution. I had taken osteoporosis meds by mouth before and always had issues. Right now my osteoporosis is pretty bad. I have it in my spine, hips, neck and who knows where else, so I need to find something to stop this and get my bones back in shape. Does anyone have any thoughts on Boniva iv solution? I also thought of Reclast but am not too sure about this one. Thanks.

        • Kathi October 27, 2014, 10:13 am

          Also, my osteoporosis is too far gone so I’m wondering if a natural approach is going to help me in reversing the bone loss.

  7. Paula August 12, 2014, 10:28 pm

    My mom is 79 and has severe osteoporosis and has recently had 2 fractures in her lower back. She is in a lot of pain. Her doctor is telling her that taking Provlia is the way to go and is safe so she is considering the drug. I am concerned with everything that I am reading that this is not a good idea. Unfortunially older people put to much trust in the doctors today.
    I don’t know what to do…she is in a lot of pain and not able to function in her everyday life in the state that she is in now. So it sounds like she is damned if she takes the drug and damned if she doesn’t because she can’t fountain the way she is.
    Any suggestions…Thanks for listening.

    • susan February 10, 2015, 7:37 pm

      I am 69yrs old and have tried alot of Bisphonates and am now on Prolia 2yrs. I have fractured 4 lumbar verts and 3 thoracic verts and I had 2 kyphoplasties done on my lumbar spine which immediately took the pain away> Have you heard about this proceedure? I think it is great for someone who is in alot of pain from lumbar fx’s. but it has to be done within 6 weeks of the fx to help.

    • Vivian Goldschmidt, MA August 14, 2014, 8:00 am

      Paula, do you have the Save Our Bones Program that you could share with your mother? Maybe she would appreciate if you’d direct her to this site or print out articles and information that might be helpful to her. Then she can make a truly informed decision!

  8. Nick August 7, 2014, 6:09 am

    My wife is on her 4th Xgeva injection. She had one dose of Zometa prior to Xgeva but shifted when she experienced body pain. She did experience mild pain on her first dose of Xgeva & none on her 2nd & 3rd. She will have her 4th tomorrow. She has bone mets & recently underwent radiation which lessened the pain by at least 50%.


    For how long should she be on Xgeva?
    Would lab tests show if Xgeva is effective or MRI?

    We are from the Philippines.

  9. Audrey Aspeling July 6, 2014, 5:12 pm

    I wrote before in 2012 with my belief that our continued and increasing exposure to low dose electromagnetic radiation from wifi, mobile and cordless phones and their masts and all the other modern electrical and wireless gadgets may be affecting our bones so looking to reduce this may help you all and even prevent cancer and many other diseases. I built my new back bedroom to get away from excessive power lines I spoke of before and then needed grounded shielding paint and curtains for the radio waves and have had some improvement without any bone density medications. I still cannot avoid exposure in the day but the night is most important because we need to produce melatonin then to heal us and cannot do so with electricals in the bedroom. If you don’t believe me just look up EMR and Health!

    • JudyAnne October 13, 2014, 6:31 pm

      Hello Audrey, This sounds very interesting. Thank you for sharing this info with us. Much good luck and I hope you get on your way to good health!
      I’m 71 and just had a horrible bout with 1 injection of Forteo, Friday October 10 2014. I have severe rheumatoid arthritis, fibromyalgia, and severe osteoporosis, plus lung and heart health issues.

  10. Doris June 30, 2014, 10:49 am

    I got my first and only shot of Prolia in May 2013. Four to six weeks later, I developed fever (101), chills, and flu like symptoms. Several weeks later I began having bad heart palpitations. When I called my doctor, she did not think my symptoms were side effects from the Prolia, but I refused to take more shots. My doctor did order blood tests. These tests showed my thyroid and pituitary gland readings were way off. At first she had me cut my thyroid medication in half and then took me off of it as the second blood test was even more skewed. She had been treating me for low thyroid. I am still having an irregular heart beat which can leave me weak at times. So far EKGs have been inconclusive as to heart issues. I wish I had researched Prolia a little more before agreeing to the infusion.

  11. Ramona June 24, 2014, 3:34 pm

    Glad to find this thread. I live in Georgia and was fortunate to find a pharmacy that works closely with the company who makes Prolia. The regular price through my local pharmacy was way too high $$$ for me and it was a mission getting the insurance to pay for it. South Miami Pharmacy helped obtain the prior authorization finally AND they also have a copay assistance program that helped with my high copay. The staff was great. They didn’t charge to ship it to me next day. Hope this helps.

  12. Rina June 15, 2014, 5:22 pm

    I had a Prolia injection November 2013. By March 2014 I started feeling cold spells, not flue, but just feeling cold, shivering when others felt warm. I met the specialist that prescribed the drug and he said it’s o.k., it’s not the drug. I was stupid to take his word and not do the research myself. So, May 21, 2014 I did my next injection. 2 weeks after I started feeling so cold that it felt as though my bones are in the freezer and a week after that, bones in my hands and legs started hurting. I can say with surtainty that all these side effects are from Prolia.
    My advice to people: NEVER TAKE ANY MEDS that last longer than 24 hours. At least if you get a side effect you can stop. I don’t know what will happen until Prolia will go out of my system by November 21, 2014. I hope there won’t be any permanent damage and I won’t die.

    • Vivian Goldschmidt, MA June 16, 2014, 8:17 am

      Rina, your body is remarkably adept at removing toxins, including medications! The process is greatly enhanced if you support your cleansing organs (kidneys and liver). I encourage you to check out OsteoCleanse – you can read about it here:

      Take heart! Your body is designed for health, not disease. :)

  13. orit May 11, 2014, 7:20 am

    my mother got prolia and after 3 month got something like mycosis fongoids/eczema
    T cell .
    do someone know the conection between prolia and Tcell?

  14. joy April 10, 2014, 2:26 pm

    Vivian granted that your stuff is that good why not share it with the suffering people,we are already paying with our bab bones, let your knowledge come out athe world will be gratefull at you.

  15. Tricia April 6, 2014, 7:58 pm

    Doc telling me I have to take prolia. Bone density of -2.8. I’ve never had fracture, in good health, and follow good diet. I don’t want these prolia side effects at age 88. They say my hips are in red zone Help! Please! Any suggestions or advice. All I read about prolia and friends say it’s bad. Docs won’t hear of anything else

    • Joyce June 5, 2014, 7:30 pm

      I took Prolia shot 6 months ago. I have severe arm pain. I canceled appointment for second shot. I will not take it again and would not recommend it to anyone.

      • Vivian Goldschmidt, MA June 6, 2014, 8:55 am

        I am sorry you experienced that kind of pain, Joyce! Good for you for not being afraid to say “no” to more treatments. :)

  16. mavis March 12, 2014, 8:01 am

    Vivian you are a disgrace
    can you please show me one bit of clinical evidence about your money spinning garbage that you are selling. Please women listen to your dr not some hack trying to sell books. She won’t be here in 10 years when you have a hip fracture and end up immobile she will be in the bahamas enjoying your money.
    shame on you Vivian

    mavis -76yo

  17. Rita March 8, 2014, 2:13 pm

    I have week bones. In 3 years the scan showed that my bone density went from -2 to -3.6. I had 2 fractures last year: Patella and ankle. I tried all natural remedies (bought Save our bones book few years ago) and it is not stopping my bone loss. The doctor suggested to take Prolia and I read many articles available on this drug.
    I have to do something just not sure what. Any suggestions?

  18. Glenda February 26, 2014, 11:21 am

    I am almost 63 yrs old and just went for my annual physical to my gyno. I told her about my Dad who’s almost 85 who has been diagnosed with mini strokes 4 yrs ago and in November he finally fell just the right way and broke his hip. I was only telling her this to update her on my “family history”. She immediately applied that to me that this incident makes my “likelihood” of breaking a hip up 3xs. I was shocked to see that as a correlation to me with his age and his condition being the “cause” of his hip breakage. She said it doesn’t matter unless he fell off a 3 story building. She was adamant about that. She knows that I have refused further “medical treatment” that the drug industry offers for years now. I have previously been on Fosamax, then Boniva, then Fosamax again. When my bone density tests proved that I had osteo. she then recommended Reclast intravenous injection or Forteo. That was a few years ago. When I realized that this is an injection, I said “Whoa” let me check this out. So I went online and saw all the negative reviews that people had to these drugs and also found Vivian’s site. I was highly impressed that someone had put so many years of research into this one area and had come to these conclusions. I have bought the Save Our Bones program, but quite honestly did not “get around to reading the book”, a downfall of mine with good intentions. So I’ve just trudged on, waiting to see how things go without using drugs. This time when I asked her about when is it time for my next dexascan, she said what’s the use of getting one if you’re not going to take a medication, those are very expensive. So that surprised me, because she feels that no “natural” method is going to improve your bone density therefore there’s no use in having the test. (Besides, my insurance has always paid for it, so is she implying that she wouldn’t even prescribe it for me?) I decided not to argue with her, she asked me to reconsider taking the Provia, which is the latest “best” bone drug in her opinion. I said I would reconsider. I asked her if there were any side effects, and her reply was, “why yes, there’s possible side effects to any drug you put in your mouth, even Tylenol”. I thought that was a pretty “glib” answer. DUH! Yes, but what are the side effects and how severe can they be and do I want to be a guinea pig to see if I’m the unlucky one of a “few” that get these terrible side effects or look elsewhere. I think that doctors are “pushing” drugs, because that’s all they know to do. She said, believe me, if there was a natural alternative that would work, I’d be all over that. When she first tried to get me on Reclast, and I did all that research, I forward this info to my doctor and she met that with some resistance. I don’t know what to do at this point. These medications scare me, but she scares me of a hip breakage too.

    • Catrina Arnold November 20, 2014, 2:21 am

      It sounds like the same pharmaceutical sales rep visited both my doctor and yours. It’s the “best” bone drug there is, “look up Tylenol if you’re concerned about side effects.” Funny thing is the insurance company pays the doctor for doing the injection at his/her office, unlike prescriptions that get filled at a pharmacy or (yikes) supplements and exercise. Prolia may turn out to be an excellent treatment for osteoporosis but it seems to be a bit early to tell. The FREEDOM study looked at patients over a 3 year period yet many of the problems with bisphosphonates didn’t show up until after 5 years? Haven’t totally ruled Prolia out, but am certainly giving it a hard and thorough look.

    • Vivian Goldschmidt, MA February 27, 2014, 7:22 am

      Glenda, it’s clear that you are thinking through your choices and doing your research. Good for you! I want to encourage you to make your own health decisions; no one can “make” you take a drug you’re not comfortable taking, period. It’s not your doctor, but YOU who will experience any side effects from medication! So empower yourself with knowledge, and don’t be afraid of taking the “road less traveled.” :)

  19. Kay February 21, 2014, 1:50 pm

    Was diagnosed with osteoporosis 4 months ago. Had a tooth removed so could not take the Prolia injection for 2 months after the “site” had healed. Got the Prolia injection exactly 2 months ago (12-21-13) About 4 days ago started having horrendous low back pain – went to the Ortho dr and he gave me pain pills – Trama-dol (that don’t even take the edge off) and he has ordered an MRI that I am to have next week. Also have just started experiencing some dizziness in the last couple days. After reading all the comments I am now wondering if a 2 month long struggle with bronchitis and lung infection in which 2 different antibiotics didn’t even phase it that my immune system has been compromised. I have contacted (today) my family physician and the ortho dr in writing telling them all this and am waiting to hear from them. I won’t be getting the next Prolia injection in June.

    • Clarisse August 15, 2014, 1:16 pm

      Eu tomei Prolia a dois meses atrás e também senti sintomas parecidos. Começou com uma dor nas costas e dias depois muita tontura, náusea, dormência nos braços e falta de apetite. Agora estou melhor, relatei esses sintomas para minha médica, mas ela me disse que não tem nada a ver com Prolia. Ela disse que se fosse algum efeito colateral teria aparecido nos primeiros dias. Outro médico me recomendou que eu tomasse a vacina de meningite ACWY, mas estou preocupada em ter alguma interação medicamentosa com Prolia. Alguém tem alguma informação sobre isso?

  20. Mimi January 24, 2014, 1:20 pm

    IV boniva??? I am 55 y.o. diagnosed with osteopenia in my mid 30’s. Now at the age 55, I have severe osteoporosis with past spinal fx. cervical and spinal surgery, with R/A fibro, bla, bla, bla… lol.. I have been on vioxx, forteo and prolia with extreme side effects just as all of you, flu like symptoms, fatigue, pain throughout, inabilty to eat properly, weight loss of 60 lbs due to dental pain and my teeth are twisting with jaw bone pain. After receiving an injection of prolia I had so many side effects, I called and left my Dr. 4 messages, 2 times I walked in and left msgs. he never returned my call. 2 mos. later when I finally had an appt. he said to me he did not have 15 min. to call me (very sad). He refuses to do any labs on me except for a vit. D. Once I saw him he assumed I was still doing well on the prolia, at the time he denied the issues I was having were due to prolia he said it was anxiety lol. I saw him 4 mos. later this past Wednesday and he admitted that my issues indeed were from the prolia since they happened during the time I was on this med and have let up while off. He now wants me to try another posion called iv boniva. People, I am so frieghtened because if I have issues he does nothing about and assumes I am still doing well on what ever the last oste drug he sugggested, NOT, ther is no one to turn to. I requested he put me on miacalcin and he laughed and said “that was pulled off the market because we have these other great Osteo drugs”. I called the pharmacy to see when this miacalcin was removed from the market and the Pharmacist said we still have it and it is used by many with great results. I can’t stand someone that lies to me, especially my rhuemotologist. The rhuemotolgist prescribes these bad drugs then WE must pay our dentist to go above and beyond what was initially required prior to receiving these poisons. Help any input would be helpful. thx

  21. Ray January 13, 2014, 9:29 pm

    I realize bisphosphonates aren’t completely safe, but they do help some and don’t harm everyone or even a high percentage of people. I have pretty severe osteoporosis with multiple spine fractures prior to taking Fosamax and now Prolia. Of course if you didn’t exaggerate the amount of people that have side effects with these drugs and use the scare tactics that you do, you wouldn’t be able to make money selling all of your “Save your Bones” products.

  22. Julia Guinasso January 4, 2014, 11:32 am

    Enormously educational thanks, I do believe your visitors will possible want further blog posts like this maintain the excellent effort.

  23. Beth Vandesteene November 2, 2013, 2:14 pm

    I am scheduled for my second shot November 11th, however I have decided not to get it. I have had aches and pains like I never have had before. I lost 10 lbs and I am a small person already weighing only 110 my normal weight. I figured its just the way it is for some time now. I can barely walk the past two months because of foot, back, and neck pain. I go to a chiropractor which worked great till my first shot. I am only 58! I have tried Actonol, Reclasp, which did nothing to improve my bones. I went to the podiatrist, who gave me inserts, which crippled me in just 6 hours. Turns out he says I guess that’s not you’re problem . SO he gives me a series of shots between my toes. Provided only some relief for a short time. Its back. OMG I even went to my Primary because I felt I was not breathing right. These guys knew I was on Prolia and never mentioned it could be related. Because I am a former smoker he says I have COPD! Guess what he prescribed! I believe I do not have COPD because it made no difference in my breathing symptoms.
    I think I have finally smarten up!!!! I know my body and it says enough. Thanks for listening. I will be checking out you’re website for sure.

  24. Marie C Tona November 2, 2013, 6:27 am

    I have had terrible! headaches! ever since I had this shot. At first I thought I was havering a Migraine took an Imatrex and figured it would pass. It did and I slept, when I work up it was back. I have had headaches, day in, day out for over a week 10/24/13 now from morning till night. Goes from from mild to severe, but never goes away. Take a sleeping pill to get to sleep.Have had gastric pain every day. I can only get nine Imetrex pills a mo. Insurance won’t pay for more. I have Fibromyalgia. Can’t tell if all the aches and pains that never go away are from my Fibro or the shot. I feel awful. Taking a pain pill will only cause severe abdomenl pain. See my pain specialist next week, and hope to get some relief. Right now she has been treating me for my sciatica hip pain, again insurance will only pay so much, her hands are tied. I can’t believe I will have to live with these constant! headache for six mos. Very diffecu;t to watch any T.V. if at all.Constipation is a problem. Had Botox for Migraines couple mos ago. Have had Botox the last couple yrs, with great success. I will never, ever, have a Prolia shot again. I am so tired. I’m hoping these nasty headaches will soon go away. Going to use my Restasis for Dry eyes now and go to bed, hoping for a better day tomorrow.

    • Vivian Goldschmidt, MA December 31, 2013, 12:57 pm

      Marie, it saddens me so much to hear what you are going through. :( I really hope your pain specialist can help you find some relief, and if you are interested, you are welcome to check out OsteoCleanse (in Products) to get the Prolia out of your system faster. Hang in there!

    • Marie C Tona November 2, 2013, 6:37 am

      Has anybody had this problem, if so how did you handle it. Did it eventually go away. I’m at a lose what to do. My Primmery Doctor said this Med was not for me. Meanwhile what do I do, if anything. I am hyper sensitive to all Meds. It sounded so good when the nurse explained it to me. Not so. Did you get my comment?

  25. Lowana October 28, 2013, 8:40 am

    Hi Vivian, I went off Actonil for almost a year, then unfortunately fractured my sacrum and Dr. talked me into having an injection of Prolia one month ago. Could I start the cleansing diet now or do I have to wait until the 6 months is up?

    • Vivian Goldschmidt, MA October 28, 2013, 7:33 pm

      Lowana, you can start the OsteoCleanse program or the Save Our Bones Program any time! :)

      • Sunny December 31, 2013, 7:52 am

        I don’t trust people like Vivian. If her research is so great, then why isn’t she publishing a peer-reviewed study? Why doesn’t she have an MD? Why is she instead trying to make a profit by selling her precious info? Anyone who thinks Vivian has your best interests at heart is foolish; she’s trying to make a buck and is no better than any other huckster.

  26. pożyczka pozabankowa October 11, 2013, 6:30 am

    About a year ago I felt a bulge in my left butt that resulted in 5 bulging discs, L2-5 and S1. I decided to see orthopedic, chiro, MD also had MRI and xrays that showed bulging of 2 discs. In my case, nothing worked although I had 4 epidural injections and doctor prescribed pain medicines as well but the pain became worst even with heavy painkiller. I have tried many options but my problem is still there, I really need sincere advice about the type of Dr I should see. Thank you!
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  27. Donna September 19, 2013, 1:59 pm

    I read your book and have adhered to the dietary guidelines as closely as possible for a couple of weeks. I think I may turn into a vegetable! Only twice in that time has my urine testing showed alkaline. What else can I do? Also I am losing weight which I don’t want to lose! Help! Donna in Georgia

    • Customer Support January 7, 2014, 7:09 am

      Hi Donna! Please send us an e-mail at Customer Service by clicking on the smiley face icon at the bottom of the page, or sending a message to We look forward to hearing from you, and are glad to help answer your question.

    • Rebecca Minier December 31, 2013, 7:47 am

      Interesting that Vivian hasn’t bothered to respond to your question. I think she’s a quack. Anyone who advises me to ignore my doctors’ advice, yet has no MD of her own doesn’t deserve the time of day.

  28. Patty September 10, 2013, 5:35 pm

    I’ve had two Prolia injections and am due for my third.
    I am 63, fell 10 years ago, fractured three vertebrates and began taking
    Daily injections of Forteo.
    I was achy the first three months, which passed. During these two
    Years I began to have thumb pain in both hands. I went to a doctor
    Who gave me an injection of cortisone in each thumb and I was fine.
    However since taking Prolia I’ve found my hands and finger tips are
    Increasingly painful and when lifting weights or using my elliptical
    The pain is becoming very difficult to live with. I just received another
    Set of cortisone injections into my thumbs. On occasion I get shooting
    Pains in my elbows and lower arm.
    It could be a coincidence, age or Prolia.
    I am wondering g whether I should Fodor my third Prolia injection
    Or discontinue. It is a real concern.

    • Vivian Goldschmidt, MA September 11, 2013, 3:03 pm

      The decision is yours, Patty. If you do decide to stop the Prolia, I am sure you’re aware that there’s a drug-free alternative available! :)

      • Dael Segar March 11, 2014, 2:55 pm

        I had my first shot of prolia last November. After about four days I woke up stiff and in pain all over. This subsided into stiffness in my hands, feet and knees. I will not be going back for my second shot and am hoping the pain goes away as the drug leaves my system. Dael S.

  29. lorna hayes September 2, 2013, 12:38 pm

    I am a female age. 67 and have low blood calcium so bad I can hardly walk for the past three weeks and did not realize it was all due to Prolia and the muscular lower back pain that came with it.I trusted my rheumatologist because I complained about lower muscular leg pain and he says I am not buying the right shoes.He knew I have osteoporisis and I was on no medication due to other medicine not working like Boniva. I could not take Fosamax because of esophagheal reflux. Yet he recommended Prolia and now on my second injection it almost killed me with low blood calcium.I am not going to take anymore fancy medicine except calcium and vitamin D. Anybody thinks that is bad also?

  30. lorna hayes September 2, 2013, 11:08 am

    My second time taking this injection because I was afraid of osteoporosis and had three previous bone fractures in my life so far. I had parathyroid surgery in 2011 and informed my rheumatologist of this and could not take any other medicine like Boniva. He recommended this. The first year I took this injection it was not painful. Just noticed some arm pain and jaw pain. Now I have been confined to home for a month and missed church and went to the emergency room and they diagnosed me as having a sciatic nerve problem up and down my lower back and left leg.Put me on Prednizone and celebrex and still 10 days laterhave the same symtoms.Thank God I kept the prolia brochure and recently read it and now realize it was due to this injection. I have low calcium blood level and fatigue and can barely walk.Its labor day week-end and no way to help myself until my doctor opens office. I am considered intelligent and didn’t want anymore broken bones,but guess what? These side effects and pain is so great,its not worth it. I don’t know how to get rid of this serum in my body and I took my second shot in May of this year,I am totally disgusted.

  31. Sunny Nelson August 8, 2013, 10:16 pm

    Thankyou for your most informative article about “Prolia” I have an endocrinologist who keeps pushing me to take this drug! I already have a comprimised immune system resulting from severe R.A. and medications I need to take for that to function. I am age 70 now and I will not risk anymore damage from drugs.

    • Vivian Goldschmidt, MA August 9, 2013, 1:48 pm

      I am so glad to hear that you’re making your own health decisions, Sunny!

      • SuzyQ January 2, 2014, 10:01 am

        Really, Vivian? Don’t you mean you’re glad this woman might buy your cure as opposed to listening to an actual doctor?

        I’ll bet you are.

  32. Rita August 4, 2013, 3:40 pm

    I have been prescribed Denosumab to counteract bone loss from the breast cancer drug arimidex. I was previously osteopenic before the breast cancer. Having read the side effects from this drug I am now very concerned. My first treatment is scheduled for Friday.

    • Jean November 28, 2014, 6:19 pm

      Rita, I’d sure like to hear what happened next. Nine years post-surgery (lumpectomy) followed by radiation and 5 years of Femara, it’s unexpectedly been discovered that my CA has returned, now in my spine. I’m back on Femara, but my oncologist wants me to agree to every 4-week injections of Xgeva (Denosumab). I’m very reluctant to agree to it, but am having trouble finding a clear cut answer. My first injection is scheduled for Dec 30 because I’d refused it earlier. What did you do?

  33. sandra June 22, 2013, 1:39 pm

    prolia is a dangerous drug causeing more problems than what it is suposed to treat!iv had one injection of it and to say the least alot of side effects drs dont want to hear! i weigh the same now but look heavier isthat water in the tissues? more muscle pain.and i have fibro ,cfs and injuries so its not good for all of that either!
    now my blood work is showing inflmation and have to see another dr if its inflamation of the heart? well think your company is in big trouble.
    im so sorry i took it and will not take it again, im useing a good calcium
    and vit d magnisum and will take my chanches rather than more health prolems from a drug they are useing us woman as gini pigs!!!!!!!!!
    and thats the real truth!

  34. Eugenia Kayiannis May 28, 2013, 6:11 am

    Hi there!
    I’m an SLE patient since 11 years old (42 no). I take medicine all my life. Due to big doses of prezolon, when i was 18, we discover that I have osteoporosis (-2,6 hip) 6 yearsago. Since then I’m on actonel, no side effects, but because of my nephritis the doctors said that I will soon go on prolia. Do you think that I can try the non-osteoporosis’ drugs program? For 20 years now I’m on 5mg prezolon.
    Thank you!

    • Maggie August 31, 2013, 2:38 pm

      Dr. Charles E. Price has published a book titled “Can you Feel It In Your Bonces? and developed a supplement to treat osteoprosis. I have refused Prolia, even with
      the scare of a broken hip, and lack of medical treatment. I refused the injection required by my Physician, and have been using the supplement from the institute for Better Bone Health, Check this out.

    • sandra June 22, 2013, 1:40 pm

      id use the program rather than andy of these injections drs push on you

    • Vivian Goldschmidt, MA May 28, 2013, 8:07 am

      Eugenia, I want to encourage you to make your own decision regarding your bone health! You’re already on the right track because you’re part of the Save Our Bones community and are clearly doing your research. Good for you! The decision to go off of osteoporosis drugs is entirely up to you. If you do choose to take the drug-free route, remember that the Save Our Bones Program is risk-free! You can return it for a full refund within 1 year of purchase – no questions asked. I wish you excellent health, whatever you decide!

      • sandra June 22, 2013, 1:41 pm

        way to go!

  35. D Nick Bonardy May 24, 2013, 10:36 pm

    I want to thank you for responding to my Query on ” Prolia ” Why do these drugs get approval from the FDA ? They will kill you quicker that you can get well . No I don’t use drug/prescriptions I use natural/Holistic supplements instead . I saw this Prolia being advertised on TV and also noticed the side effects ! Do doctors who prescribe, this know about the side effects ?

  36. Konnie May 21, 2013, 8:59 am

    I had my third Prolia injection one week ago and am having many of the adverse symptoms. Short of breath, rash/hives, muscle, joint and bone pain that doesn’t allow me to sleep. What can I do? This poison will continue being released in my body for six months!
    Any thoughts are appreciated.

    • Sharon Wilson June 23, 2013, 9:58 pm

      I am having the same adverse effects after having this injection 1 1/2 months ago. I have Rheumatoid and well as Osteo Arthritis and Osteoporosis. I have infusions of Remicade for my RA and it was helping a lot before the Prolia. Now I need to know how to get this stuff out of my body. I do not recommend this medicine. I can barely walk and have so much pain in my back, my legs and now my left arm is really hurting- therefore no sleep. My skin is flaky dry. It was all ready dry but now much worse. I had my Remicade two weeks early because of a flare up but have not had any relief and that was 5 days ago. I hate to think what will happen if something isn’t done soon to reverse this. Any help would be greatly appreciated. I am a 65 yr. old woman. Thank you and God Bless.

      • Vivian Goldschmidt, MA June 25, 2013, 8:18 am

        I am so sorry to hear that you’re experiencing those issues, Sharon! I hope you’ll take a look at Rapid Cleanse, the 7-Day Cleanse that’s designed to remove those toxic drugs from your system. You can read about it here:

        Remember, your body was designed for health and wellness!

  37. Judy May 20, 2013, 1:25 am

    I feel that Prolia is the only way that I will be able to save my bones. I have tried other meds. but I couldn’t take them, they made me sick.
    Would really like to try a natural way so that I wouldn’t have to take meds.
    I am scared to death of the side effects.
    Judy D.

    • Observer July 14, 2013, 4:36 am

      Judy you are not listening! If you read the e-mails in this forum and you still think that Prolia is the solution to your problems then no doubt dear you deserve what is coming to you.
      Open your eyes and refuse to become another experiment.

  38. Judy Summers May 16, 2013, 12:02 pm

    Hi, I had one shot of Prolia. No one warned me about these serious side effects. The shot was given to me in March of 2012. Meanwhile my jaw began to bother me so much that I have a hard time opening my mouth. I also was diagnosed with lose bottom teeth at my last dental check up. I do have more muscle aches than before and my 2 bouts with the flu this year lasted a few weeks instead of a few days! Also I still have pain in my left arm at the injection site! I can still tell where they gave me the shot when I press on the muscle. I did know about the jaw issues with Actenol as I had to quit taking it when I had a dental implant to replace a dead tooth! I am a stroke survivor so I do question why my doctor prescribed it to begin with! Please continue advising women about these drugs. Oh my mother had been on Fosemax for years before she fell and broke her femur. She is now wheel chair and walker dependent! Sincerely, Judy Summers

    • Observer July 14, 2013, 4:40 am

      Judy, are you really saying that your mother broke her leg after being on Fosamax for years? Shouldn’t her bones have become unbrakeable by now?

    • Vivian Goldschmidt, MA May 16, 2013, 1:12 pm

      I am truly sorry you and your mother have experienced those issues, Judy! :( Thank you for sharing, and I hope with all my heart that you are able to nourish your body and build your health and bones.

  39. Dee May 4, 2013, 1:40 pm

    I took Alendronate (generic for Fosamax) for 4 years and my bones went from osteopenia to osteroporsis in that time. I then got off the drug and on to Prolia shots. Have had 2 the past year and my results improved from osteporsis back to osteropenia. I have had no side effects. I’ve read all comments made and the best one is: All drugs have side effects. Some people get them and some don’t. If you had cancer, you wouldn’t reject treatments knowing the side effects beforehand. And as one of my doctor’s told me..try it. If it works, great, if it doesn’t then stop. Yes, I’m concerned about the drug. But some people are afraid of planes and some aren’t. It’s mostly the negative remarks that get written up…

    • Lone November 25, 2014, 6:56 pm

      Hi Dee, my endocrinologist has also prescribed Prolia for me. I’m concerned. I’m 52, have coeliac disease and t score -2.7 spine and -2.5 hip. Not sure what to do after reading about all these side effects. Due for my first injection in a couple of weeks, in the mean time I have been put on Thyroxine 50mg due to slightly underactive thyroid. Glad to hear you have seen improvements.

    • Observer July 14, 2013, 4:48 am

      Aren’t medicines suppose to make us better?
      We are not supposed to sample everything the doctors hand us on the basis that it may work or it may not. This is not how the health of people should be handled. This is good for playing games of chance like Lotto or blackjack but definitely bad where it concerns our health!

    • sandra June 22, 2013, 1:42 pm

      no its not mostly negative reports iv taken it and the side effects are REAL!

  40. David Helms April 27, 2013, 10:41 am

    I am uncomfortable with the prospect of Prolia but I am being told that because I have hyperparathyroidism coupled with osteoporosis I must take the drug.

    I am also told that my bone density score is 5% less each time I take the test which is yearly.

    The problem with this assesment is I never know what my starting density was or a t score so without knowing what I am deducting from I don’t know my risk. I do know I have gone from osteopeni to osteoporis over the last couple of years and this last test showde incredible spine whiteness on the film attributed to arthritis. Finally in all of this I had one bone density reading of + 3.5 bone desity which no one talks about or seems to use in the bone loss calculations. Where Can I get more information on my situation.

    • Observer July 14, 2013, 4:51 am

      Why don’t you get a second opinion without mentioning what the first doctor told you? Try it as you may get pleasantly surprised!

    • Vivian Goldschmidt, MA May 16, 2013, 1:14 pm

      David, please remember that bone density is just one aspect of bone health! Mainstream medicine focuses so much on density because it needs numbers (i.e. fixed parameters) to prescribe drugs, so most doctors follow the same protocol.

      While density is an indicator of bone metabolism, the main focus of bone health is simply to prevent fractures, and as Vivian explains in the Program, less dense but healthy and renewed bones have better tensile strength than thicker, denser, older bones.

      Best wishes moving forward, whatever you decide! And please continue to read and contribute. :)

  41. Inez Morley April 25, 2013, 12:14 pm

    In 1987 was the first collapse of a vertebrae, #12 then diagnosed with osteoporosis. I’ve taken various drugs for this ailment but in 2012 in March #s 1 and 5 collapsed. I’ve never been without back pain since 1987 but in June 2012 had a vertebroplasty injection and since that date have been pain free. Had my first Prolia injection October 2012 in my stomach, no reactions and in April 2013 had my second Prolia injection felt a bit under the weather but don’t know if from Prolia. After reading all the above comments am due in October to have another injection and don’t know what to do. I also take D3 and calcium but would like to dispense with all pills but am 85 so perhaps I should just continue and hope for the best.

    • Observer July 14, 2013, 4:54 am

      Whatever you decide to do do not stop taking D3 and in large doses.
      I wish you to be a hundred and pain free.

    • Konnie June 10, 2013, 12:30 pm

      I had reactions to my first and second Prolia shots, including chronic pancreatitis but, within two hours of my third, I went into full anaphlaxis (sp) shock and had depleated calcium levels. It has been a progressive reaction. I’m on seven different medications, including steroids and a home nebulizer, to manage the side effects. The shot will be active until November 2013. I am now having severe abdominal pain that I’m thinking may be related as well.
      I will never accept another dose and cannot wait until this one is out of my system.

      • Lone November 25, 2014, 6:59 pm

        Konnie, your reactions make me really worry about whether I should go on Prolia or not. I sincerely hope you’re better. Take care.

      • Observer July 14, 2013, 4:56 am

        Try Vivian’s method to clear the effects of the injection. You do not have to suffer until it wears out.

      • sandra June 22, 2013, 1:45 pm


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  44. Charlotte April 10, 2013, 5:56 pm

    What are we suppose to do if all the drugs your doctor reccomends have all these terrible side effects, and there don’t seem to be any other sort of treatment. I guess we have to just accept the disease and learn to live with it. Calcium does not help either. I have been taking AlgaeCal for 6-7 months and my new dexa is worst than the last.

    • Jan April 17, 2013, 7:42 pm

      Have you been tested for Celiac? Once I went on a gluten free diet, my bone density increased by 10% in just the first year. It’s a simple blood test. It’s best to get to the root cause of your osteo before taking any medication.

      • Lone November 25, 2014, 7:02 pm

        Hi Jan, I’m also coeliac and interested in knowing if you have osteoporosis and if so, which medications are you taking? Even after diagnosis about 5 yrs ago and changing my diet my bone density has worsened. Thank you.

  45. mabia February 14, 2013, 3:53 pm

    About chronic diseases, could you imagine if people got off the bad vegetable fats, and the
    bad carbs, plus processed foods, you may have a population that may be almost disease free.
    Look at the start of the twentieth century, There was pockets of communities that were still
    isolated from the modern world. These people grew their own crops and slaughtered their own
    meat. They were disease free, till roads and shipping were linked to them. Shops were soon
    set up. They sold things like white flour, sugar, jams and condensed milk. The rest is
    history, we have generations brought up believing in the “lipid Hypothesis”, saturated fat
    causes cholesterol. Cholesterol causes heaart disease. That is crap. Saturated fat is
    essential for metabolism, growth and fighting disease

  46. Jude Telford January 24, 2013, 6:38 pm

    I take Prolia ( newly prescribed for me ~> osteoporosis ) . I am 67. … I now have concerns . I have dramatic prickly pains in my right upper arm , my jaw hurts at night then recovers in the day , knees hurt , left shoulder very sore when I try to sleep …. and generally I feel grumpy . I get really tired and fall asleep in the afternoon (maybe because I sleep so badly at night due to neck and shoulder pain … ) … my eyes look creepy . I used to have nice big brown eyes now they are slits … I can`t lift heavy stuff … I have a feeling there is a better way to deal with this stupid ailment (thin bones ) . I have an identical twin sister who does not even have my ailment ~~ this is unfair ! and I shall be reporting to the folks who devised twindom …. hmmmmmf ! I would like to punch someone but I do not wish to hurt my fragile fist .. (weak joke , half true ) …

    • Vivian Goldschmidt, MA January 26, 2013, 1:47 pm

      Jude, you are right – there is a better way to deal with osteoporosis, and you’ve found it! :) I hope you will check out the Save Our Bones Program. I do hope you recover your health and bone strength fully.

      • Dee Gebert August 11, 2013, 4:38 pm


        I have recently been diagnosed with Osteoporosis, and was given a script for Alendronate. I took 3 doses, during which time I began experiencing gastrointestinal problems, and general aches and pains. I stopped it and began researching my options. What I found was alarming. Like others who have posted, I am not interested in benefiting big-pharm at my expense. They seem to be concerned about profit, not the health of people. I am interested in learning more about the Save Our Bones program, however I’m skeptical. I do not intend to be disrespectful in any way, nor do I think that you shouldn’t be compensated for the research and hard work you put into this program, but like big-pharm you appear to be making a profit from this. I understand that we all have to make a living, but how do I know that this isn’t just a gimmick? I am serious about finding an acceptable treatment, and I don’t want to waste time and money if this is not going to benefit me. Again, no disrespect intended. I am skeptical by nature. I thought this program sounded interesting until I saw that I have to pay for the book to benefit from this treatment. Any comments, opinions, suggestions would be helpful. Thanks.

  47. Danielle January 23, 2013, 12:11 pm

    On the year(2011) I received the injection of Reclast because the doctor said I had osteoporosis. I did well, no side affects. This past year (2012), my doctor said I had osteopenia, and asked me to take Prolia that was even better than Reclast. So I agreed. In late August I received the shot in the arm. A few weeks after, I noticed my muscle where I received the shot was so sore it was hard to put the car in park lifting that arm. I thought it would eventually go away, maybe it was something I did that caused the soreness, maybe a wrong move. But the arm got gradually worse and had to go to the ER a saturday moring in early Nov. The doctor there gave me a shot and pills for inflammation and some pain pills. It did get better for a couple of weeks, but then the pain came back worse. I had never had trouble with this arm before, but it got where I could not sleep the pain was forever keeping me awake even with the pain pills. Then one day I had a terrible jaw pain right on the bone, which I never had jaw problems before, and all my toes on both feet and both of my hands went numb, it scared me. I know now it’s from that Prolia shot. All the numbness on both of my feet and left hand have passed and the jaw pain, but I’m still plagued with numbness on my right hand and my arm. I called Prolia and told them about my side affects and they told me to talk with my doctor. I have an appointment on Monday and hope he can help me with the pain and numbness, and hope that will wear off. I’ll be due for another shot in March, but I will not have any more shots for my bones. I eat a yogurt everyday and take Osteobyflex for the joints that helps me.

  48. mary rizzardi January 21, 2013, 3:14 pm

    I do have the save our bones program. But I need help as how to proceed daily to help me. It is difficult to process ALL THIS INFORMATION WITHOUT
    assistance. Can Vivian help me ?

  49. sodie January 21, 2013, 11:05 am

    I have had Osteopenia for nine years. I was on Fosamax for the first five years with no improvement or worsening but went off it when hearing after five years it can have a reverse affect and cause the bones to be more vulnerable to fractures. I have had two fractures, ankle and wrist. A bone density test in April, 2012, indicated decreased bone density. In July, 2012, I was placed on Letrozole which is a hormone receptor, due to being diagnosed with breast cancer. My oncologist suggested I use Prolia to counteract the side affects of Letrozole, which can cause bone thinning. A few weeks after the first injection my jaw began to hurt and it was difficult to chew food, and drink or eat hot or cold foods. I have always had excellent teeth, the problem wasn’t with them. For the most part that discomfort has gone away, but I don’t want to test it anymore and possibly make it worse. I plan not to have any more prolia injections. I am concentrating on a natural approach to increasing bone density.

  50. kcr January 18, 2013, 1:22 pm

    My doctor did a bone density test on me and said if it didn’t come back good, she was going to suggest I go on Prolia. Well my density came back fine so now I have the choice to stay on the generic Fosomax or take the injections twice a year. thank you for all your comments. I’m in a position to say “if it ain’t broke, don’t fix it”. I’ll just stay with the pills. I’m just getting over a broken foot but it did heal nicely. I’ve read too many negative comments about Prolia. Thanks for all the comments.

    • Vivian Goldschmidt, MA January 26, 2013, 1:40 pm

      KCR, you may not have realized it, but regardless of the results of the density test, you always had (and still have) the choice to stay on Fosamax, get the Prolia injections, or go off of drugs entirely. :) It’s your health and your decision!

  51. Marilyn Havens January 6, 2013, 1:09 pm

    Just wanted to bring to someboy’s attention, Some of the side effects I have had with the prolia!!!! On going rash for 10 wks now being treated with prednisone. 1st shot 4 wks later had phnuemonia, 2nd shot the rash horrible!!! I’m refusing to have anymore, & they say well its a drug reaction but we are not sure if its the prolia. Well i have decided I’m not going to be a statistic you file away somewhere. I do take vit d & calcium every day along with a good multi vitamin & omga 3’s hopefully that will help my imnume system. If anyone else has any info on this I would greatly appreciate it.

    • Vivian Goldschmidt, MA January 26, 2013, 1:37 pm

      Marilyn – and everyone else who has written in about side effects from Prolia – I am so very sorry you’ve had to undergo so much discomfort! But I am so glad you’ve come to the right place. :) Please feel free to gather as much information as you like on this website. I wish you health and strong bones!

  52. angela January 5, 2013, 3:24 pm

    I am 58 had my 1st shot of Prolia in March 2012. A couple of days later I had back pain for a few days. Nothing else, dr. said it wasn’t from the prolia. 2nd shot October I’ve been noticing for about the past month I have bone, leg and hip pain. It’s not tragic just uncomfortable. I’m unsure if its a side effect but after reading some of these posts I’m thinking it is possible. Does anyone know if side effects can occur a couple of months later?

  53. loistassello December 11, 2012, 8:39 pm

    thank you for this information. I was on the verge of using Prolia until now. I now have serious second thoughts.

  54. Legs December 6, 2012, 9:33 pm

    Hi Viv: so can a person that refuses to take prolia get their bones in
    greater shape without drugs. (I had taken reclast and other drugs without any improvementfor the past 5 years. I had a doc try to scare me into talking this to prevent broken bones. “What ever you do don’t fall” was his most frequent comment. I did hard yard labor all summer and feel like I am in good shape and stand on my feet 8-10 hours a day on my job and feel strong and I don’t have any wobbles…:-)

  55. Audrey Aspeling November 30, 2012, 10:03 pm

    I too have osteoporosis now after early menopause and some years of osteopenia. I tried Fosamax with severe reflux problems so stopped that and also refused HRT because of cardiac warnings. I have now been offered Prolia but after reading most of the above comments have decided not to have it. Meanwhile from my research after becoming Electrosensitive about 3 years ago apparently low dose electromagnetic radiation is capable of draining your bones of calcium and adversely affecting your immune system and the body’s well-being in general so as I have relatively high output from street power lines outside my bedroom window for the past 30 years I am building a new bedroom at the back where I hope my bone problems will improve. If I can find this site again after I move to the new room I’ll let you know how I go but I am sure we should all be looking at our exposure to both electromagnetic radiation and radio waves and trying to reduce that before we start taking tablets or injections to keep our bodies healthy.

  56. carol November 29, 2012, 6:41 am

    This stuff is lethal..i know i have had it..i did not recommend it all….i regret that i ever had the 2 injections that i have had..the side effects ate horrendous…pain swollen ankles that big i have to wear eee fitting shoes!!!!! never in my life have I had big ankles before like this…..I was in a wheelchair as it gave me inflammation in my thigh muscle, so bad I could hardly move…so please do not say that i recommend it…..
    I DON’T

  57. carol November 3, 2012, 11:54 am

    I have had the injection of Prolia twice now…the doctors assured me that I needed it badly as I have osteoporosis..and I was only 60yrs old! so sorry i did…..I was in a wheelchair for months as I had an inflammation in the top of my leg…in so much pain…nor i have had swollen feet for 9 months and only just found a pair of shoes to fit me in a “EEE’ fitting…I had really thin ankles before!!!! and Its made my IBS so much worst…I have to take 6 immodium tablets to stop going!!!!!!!!

  58. Eileen October 19, 2012, 8:30 am

    I am currently on Evista for two years for osteoporosis since I was afraid to take the other drugs and my bone density showed I was getting a little worse. The doctor now wants me to take this injection of Prolia – I have numerous things wrong with me and yes, I am a smoker which is a big no-no and I also have anxiety and depression issues. I stopped taking my calcium due to reading how too much can build up in the arteries and I have a very physical job so I was not exercising. My theory is that I need to cut back the smoking since I know I can’t stop “cold turkey”, exercise and start the calcium up again – I have faithfully been taking Vitamin D3 and my levels went up. I now find myself stressing over this Prolia – I do not want to take it due to side affects that can affect my jaw and I have TMJ already along with sjogren’s syndrome, IBS and arthritis in different parts of the body. I don’t have the exact T scores – waiting to hear back from the doctor if my insurance will cover the shot – but I would love to hear from other people – am I my own worse enemy with my smoking, not exercising and stopping the calcium – Evista has not given me any side affects and my gyno said it was the best one to take since the others have serious side affects.

    • Observer July 14, 2013, 5:12 am

      Eileen, what other people do you want to hear from? Aren’t the people in this forum enough? The least of your worries are whether your insurance will cover the cost.

  59. Pam October 17, 2012, 1:29 pm

    I have a multitude of health problems including panhypopit from a brain tumor. Was just diagonosed with Diabetes also. After trying all of the above menioned drugs plus calcitonin, i suffered a hip fracture while on Boniva infusions last year. My endocrinologist ordered Prolia. I get my 3rd shot today and have had no side effects with the other two. All of my previous bone density tests kept going down so I was willing to try something else. I will repost after I have the next bone density in June. So far thought I am very happy not to have any side effects and not have the gastro problems I had with the oral meds.

    • Observer July 14, 2013, 5:15 am

      You should be very happy as you are one of the 2-3% of users that have no problems. However, I would wait a little longer before the final verdict.
      I hope you remain trouble free.

  60. Kathy October 14, 2012, 12:27 am

    During the last six years I have broken six bones. I was on Actonel for five years to treat osteoporosis in both hip and spine. The osteoporosis got worse during the time I was on Actonel…..some of my broken bones occurred during this time. Then I was switched to Forteo. You can only stay on Forteo for two years but for me it did wonders because after two years I was in osteopenia in both the hip and spine. Three months ago I had my first shot of Prolia and have had no side affects. I’ve had type 1 diabetes for 42 years, have thyroid and heart issues. The thyroid and heart conditions tie into the diabetes as does the osteoporosis. I do what I have to do to stay healthy…so far so good.

  61. Margaret October 5, 2012, 1:38 pm

    I had adverse side effects including bone and joint pain, headaches, digestive problems, itching, weakness, and other problems. I went to another medical professional for help and was given steroids to help with itching. Nothing else could be done. During a follow-up visit, I was told that the Prolia drug rep came and was promoting Prolia. When told about two patients will serious side effects, the drug rep said she was unaware there were any side/adverse effects. When asked if she was aware the shot was a long lasting shot and the side/adverse effects could last 6 months or longer, she was not aware of that.

    Who paid for the studies of Prolia? Did the studies rate severity of back pain and other reactions in both groups? Who educates the doctors on Prolia safety and side/adverse effects?

    My comments….if you have no side effects, you are very lucky. People going on radiation and chemo are told and treated for side effects. The specialist and hospital involved in my injection knew of 4 conditions I have that were red flags. Both denied anyone ever had a reaction to the injection. The pain and suffering and loss of health is not worth it for me. Any drug that causes this much for this long a period of time should be reconsidered by the FDA. By the way, the other doctor to whom I went told me to report my experience to the FDA.

    • Observer July 14, 2013, 5:26 am

      The answer to your question as to who educates the doctors on the drugs they subscribe is the drug rep ofcoarse who are not medically trained and have a vested interest in the sale of the products. Besides, all the information required is printed on the paper enclosed in the box and composed by a most impartial and independent source, the manufacturer of the drug!

  62. NancyCleary October 2, 2012, 6:46 pm

    I have been on prolia for almost 3 and1/2 months and it has not be pleasing. I have suffered many of the side effects
    I am due for another shot the end of December, but at this juncture I do not think so. I would never believe what could
    Happen while on this drug unless you experienced same. Not a big fan at this time.

    Nancy Cleary

  63. Mary Ellen Smith September 26, 2012, 2:34 pm

    Am curious to know how many doctors (esp. female) are on prolia or have prescribed it for a family member.

    • Observer October 16, 2012, 6:09 pm

      A very good question.

  64. Bonnie September 20, 2012, 10:18 am

    I have Sjogren’s Syndrome as well as GERD. I have already used all the other med for my Osteoporsis My bone scan this year was not good at all. Dr. recommends that I have the Prolia shot. I’m very leary because of having the Sjogren’s Syndrome which already give me many problems that they list as a serious side effect to having the Prolia shot. So..what else can I do to keep from breaking by back, bones?

    • Observer October 16, 2012, 6:08 pm

      Certainly not to take prolia. But do not take my word, just read all the entries here and decide for yourself.

  65. Faye September 10, 2012, 10:44 am

    My Dr. put me on Fosamax about 5 weeks ago. After taking the first “once a week” pill one Sat morning, I woke at 3 am in the worse pain ever. It felt like someone had beat me with a baseball bat in my ribs. Just breathing was difficult. I had to stay in bed for 3 days as the pain progressed to my neck and other areas. The neck pain is still here and hopefully it will go away. I had to actully support my head just to move or lay down. Today he suggested Prolia. I told him after Fosamax I was unbsure if I wanted any meds. He said the scan showed I have Osteopenia? and since two years ago it is a little worse.
    I am on HRT for 4 years now, and would hope that would help I have had a gatric bypass years ago and know things are not absorbed well.
    I am glad I have read people’s experience about Prolia before taking it. I evidently had what they called a “rare” side effect. After seeing many who had the same, I am not sure it is so rare!

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  67. Mary Lynn Porcaro August 13, 2012, 4:24 pm

    Prolia was recommended by my rheumatologist. Upon calling my cardioloist with a request for his input, his assistant called me to advise that he had set aside a special time to see me to discuss this med (I have two leaky heart valves.) I am seeing him on Thursday.

    I found your site by Googling “Prolia and heart issues.” Thank you for the information presented on your site!

  68. leslie August 11, 2012, 12:11 pm

    Please tell me what can occur if one discontinues getting Prolia injections once they have had one, two or more. As a former Fosamax user (5 plus years), problems with bones are femur and hips. Some spine also. Thank you.

    • helenrushe September 29, 2012, 11:50 am

      i have osteopenia of both hips and osteoporosis of L2 and L 4 i have been prescribed protlia by my Dr having read all of the side effects I am scared to take it I am post menopausal. I have had a bone density scan and a consult with professor osteoporosis society.
      I am healthy take good diet and exercise regularly like daily

  69. Donna August 9, 2012, 9:49 pm

    I have been following an alkalizing, bone healthy diet for about 3 years (still) during which time I was also on Estrogel (and Prometrium). My bone density increased (from about -3.7 to -3.5 then to -3.2). I was also (still) on mineral supplements, high dose vit D, vit K, Biosil and ipriflavones. My doctor reduced me to bioidentical BiEst (50% estradiol, unlike the 100% estradiol in Estrogel)and bioidentical transdermal progesteron, and in one year, I lost everything I had gained with respect to bone density (back to -3.7). Nothing changed other than my HRT Rx. If anything, my exercise has increased (I am recovering from CFS). Are there some people for whom a bone healthy diet and supplements just don’t work? i.e. 100% estradiol is needed? I don’t want to take Prolia which is now being suggested.I had tried biophosphonates in the past which improved my bone density but caused a very bad GI reaction; so I quit them.

    • Mary Lynn Porcaro August 13, 2012, 4:33 pm

      My understanding is that estradiol (I take 1.5 mg daily in divided doses) preserves what is left of my bones – my last T-score was a -3.8 – and that if I discontinue taking estradiol I will lose the bone mass that was saved. I have been taking estradiol for 20+ years and do not ever plan to discontinue it.

      I am not sure what would occur if you start taking your estrogen supplement again. I would suggest talking to a trusted gynecologist regarding your bone loss and the resumption of your supplement to determine what, if any, effect the resumption of your supplement would achieve.

      Good luck to you, Mary Lynn

  70. Betty HIll August 8, 2012, 9:32 am

    I started taking foxomax, switched to forteo and now on Proleia. Forteo made my bones ache to the point I stoped taking it So far after three years I have no problem with Proleia. ‘what do yo suggest is the best source of prevention to take. Thaks.

  71. catherine lemke August 6, 2012, 1:30 pm

    My naturapath advised me to take a supplement called Bone Basics plus 2,000
    iu vitamin d3 per drop daily and walk for 1/2 hour everyday and this would be sufficient in maintaining bone health. However, I have read so many /conflicting advice re supplements – calcium, vitamin d dosage etc that I am confused. What do you know about the Bone Basic supplement?

  72. Rhonda July 19, 2012, 2:31 am

    I am a 57 year old woman with osteroporosis and have had a crush fracture in my spine and a stress fracture in my foot. The doctor suggested I go on Prolia and after reading Vivian’s comments I was afraid to have the injection. After several weeks I decided to have it and time has passed with my 3rd one due in September. I have had no side effects. One has to realise that all medications can have side effects, even panadol. If you had cancer would you reject chemotherapy or radiation because of the side effects? I wouldn’t!

  73. ethel July 14, 2012, 3:50 am

    I totally agree!!

  74. Julia July 13, 2012, 1:56 am

    Vivian you are a disgrace. You are worse that big pharma, a fearmungerer who scares women off proper treatment for their osteoporosis. I hope you are happy when women will suffer a hip fracture and die because you scared them off treatment and their BMD goes bad. I want to see your clinical trials and what you have to offer?? Useless books and herbal remedies.


    • Observer October 16, 2012, 6:01 pm

      Julia, I would say that all the entries here by the people who had first hand experience is all that Vivian needs to prove her point against anyone. These accounts are one hundred times more accurate and more reliable than any clinical trials that are very often made to order.
      I believe it is obvious that there is no profit or gain on warning people off a drug.

  75. BETH July 8, 2012, 6:33 am


    • Observer October 16, 2012, 5:53 pm

      Beth, If you had read this forum before you had the injection and you have decided to go ahead anyway, you understand that you made a very serious mistake. You should have had less faith to your doctor and more faith to the actual people here who were merely trying to help you through their own experiences. Now, it is too late to ask them for help. But I wish you well anyway.

  76. cheryl hill June 25, 2012, 1:49 pm

    I suffered a femur fracture two months ago and a stress fracture was discovered in my other leg… now my regular doctor wants me to start Prolia… she is almost too eager to put me on this medication…. I don’t want to take it and would appreciate any help … I need a long term plan but am so leery of any more medication of this type

    • Mike Smith June 26, 2012, 8:18 pm

      Ask your doctor to put you on Forteo. It’s the only drug there for osteoporosis that will build your bone back. I’m glad that you are knowing the facts about Prolia.

  77. Linda Philippi June 9, 2012, 5:39 pm

    I am so glad I have found this website. I am scheduled to have my first Prolia injection on Monday. Not anymore! I have had serious side effects from Foxamax and from any cholesterol medications I have taken. I have been so afraid to go in and take this new one. I have had so much joint and muscle pain after just three weeks on Fosamax and I just knew this new one would be just as bad. I just feel bad for all the people taking it that are having such bad reactions to it. Thank you to all the people who have left comments telling how they have done after taking Prolia.

  78. margaret May 20, 2012, 12:40 pm

    I recently had my first injection of prolia after experiencing terrible side effects from atelvia. my dr advised prolia does not get absorbed through the gastro tract, so i would not experience those symptoms. she said there were not symptoms to worry about (i found that hard to believe). it has been almost a month since my injection and i have been feeling, swollen, tired, increased heartburn, and most recently have been experiencing frequent “watery, mucous bowel movement in small amounts, accompanied by abdominal pain and upsetness (excuse the description). I am so nervous and upset that I agreed to receive the prolia, against my gut feeling. I do not know what to do, where to turn. I do have osteoporosis in my hips and severe “pre”osteoporosis in my entire spine. any suggestions?

    • Observer July 14, 2013, 5:51 am

      Margared, sure you know what to do. Just call the other two coming shots OFF and clean your body of the first shot effects immediately. I believe that Vivian can tell you how.

  79. Sarah May 3, 2012, 11:23 pm

    I had a mastectomy because of cancer found in my breast and they said got it all. Then my doctor made an appointment for me to see an oncologist so I thought I should go. He told me I should take the drug anastrozole (generic for arimidex) for 5 years to prevent cancer from coming back and wrote me a prescription for it. Then a nurse came in and said she was giving me a shot for the side effects of the drug and I would need it twice a year to keep my bones from weakening. They sprung this on me unexpectedly before I could think to ask questions. Later I found out that the shot was denosumab. After reading about the side effects of denosumab and anastrozole, I decided not to not take any more of the pills after taking them for one month. But I already got the shot (January 2012) so can’t change that but I won’t get any more. So I hope the one shot won’t be harmful but I did get a UTI recently and had to get an antibiotic for it.

    • Jose L Suescun November 4, 2012, 2:01 am

      They got it all, yeah!! This is why 96% of cancer patients die.This will surely frighten you. But I have something to sweeten it: Protocel. It puts 80% of all cancers out of business. Look for it in the internet, if you have a recurrence. No more info is necessary. Stay away from further mainstream treatments. If you could not be cured the first time, the horse is already out of the barn. You could had avoided the mastectomy, if taken in the beginning. Lack of knowledge brings tragic consequences. Cancer has been cured in the States since the 30’s and even before with alternative treatments
      My best to you.

      Jose L. Suescun

  80. gloria May 3, 2012, 10:49 pm

    Hi Vivian,
    I want to thank you for alerting me about taking calcium. Ive been taking calcium capsules for years because my doctors told me it was necessary for osteoporosis. I appreciate your advice and just cancelled my order for them. The only drugs I’m taking now is 5mg of amlodipine and 12.5mg of hydrochlorothyazide for my blood pressure which is necessary. I’m taking the good supplements like B-Complex, Nattokinase,Resveratrol and Osteo-bi-Flex.
    Thanks again,

    • Jose L Suescun November 4, 2012, 2:10 am

      Hi, Gloria!

      There a lot of natural treatments for Hypertension without side effects. I have it and took mainstream pharmaceuticals and controlled it, but with terrible consequences. I decided to stop them and my numbers went right up again. One day I started taking flaxseed oil and my BP went down to 120 and less over about 70. A large part on the American population is deficient in essential fatty acids.

  81. Dottie Welch May 3, 2012, 12:18 pm

    I am about to start with PROLIA injections which my doctor highly recommends. I have a serious osteoporsis in the hip in particular. I am so confused but at this point am planning to try the injections. In 2 years (during which time I only took Calium/Magnesium vitamins – had stopped Fosamax which I had taken for 5 years) my hip area went from minus 2.5 to minus 7.7. Naturally, I am very concerned.

    • Jose L Suescun November 4, 2012, 2:28 am

      I have been recently diagnosed with osteoporosis of both hips and osteeopenia of the lumbar spine. I am “rather old”. I will follow Vivian’s Rx and probably complement it (if necessary) with “Ultimate Bone Support” from advanced Bionutritionals. It contains Srontium, Hopps exract, L-Lysine. Vit.D3, Vit.K2. Boron, Silicon, Manganese, Copper and Zinc.

    • Observer July 5, 2012, 6:39 pm

      Dottie, I hope you took a second opinion before trying prolia. There are enough warnings here from people who took it to make you think twice about it.
      In my opinion, you have enough problems without wanting to add more, like a broken bone may be?

      • Yuana July 12, 2012, 7:33 pm

        I have been using Prolia for approx 2 years now and I have had no problems at all. My bone strength has considerably increased and I am so happy with this medication. Obviously as with any drug, certain people may not benefit as much as others. I only recommend caution, not fear. Good luck and better health!

  82. Ivana May 3, 2012, 3:48 am

    Dear Vivian,
    I wrote you about my osteoporosis & arteriitis temporalis but I cannot remember WHERE I placed my questions.
    Could you please help me to find my letter and eventually your point of view?

    Many thanks!

  83. judy landers May 2, 2012, 1:54 pm

    I will soon begin taking prolia. I have severe osteoporosis and fosamax from 1999 to fall of 2011 did little if anything to help with my very bad osteoporosis. In addition to being a white post menopausal female, my mother had sever osteoporosis (also took fosamax for years)and broke bones in her back just walking. I am of course very worried about potential side effects. I am interested in learning how others have done while on this medication. Any side effects? If so, what? Comments would be appreciated.

    • Observer July 5, 2012, 6:48 pm

      Judy there is plenty of sound advice here if you have time to read all the posts but the best answer is the one you have provided yourself. You say, your mother broke bones in her back while she was on fosamax for years. Fosamax is a top osteoporosis drug. What does it tell you? It tells me that the drug should be withdrawn and the company fined for product misrepresentation. From the accounts here Prolia appears to be even worse. I am begining to believe the doctors who claim that all osteoporosis drugs are inadequate.

  84. June April 10, 2012, 10:22 am

    I’m due for my third denosaumab injection on Friday I don’t want to go through with it having read the side effects on this drug and suffering two collapse with in ten days of having this ,and I’ve not had a bone scan for 2 yrs I’m not sure if it’s done the job it’s meant to do , I’m so confused please help ,


    • Observer July 5, 2012, 6:49 pm

      Read my post above.

  85. June April 10, 2012, 10:09 am

    Im due for my 3rd denosumbab injection on Friday .having had it twice and been unwell after it I’m really worried about it. Also I’ve not had a dexta scan for 2 yrs ,how doi know if this drug is causing me more harm than good . I’m really stressed about it,
    Thank you.

  86. Jean March 29, 2012, 8:40 pm

    I am 81 years of age. I was on estrogen/progesten for years and then went off because of the side effect of cancer. I went to fosamax for ten years. I had a Dr. tell me to go off fosamax or actenol because of the jaw disease. She gave me a prescription for high dosages of Vitamin D and calcium. I developed a parathryoid gland problem…I had surgery. Now another Dr. put me back on Fosamax because of the loss of calcium from the gland problem. I am fearful of taking the drug. I have been on it this time for one month. My friends where I live tell me to stay away from all of these alendronate drugs. No side effects as yet; however, I don’t think I have been helped from these drugs in the past. Any advice please.


    • Observer July 5, 2012, 6:51 pm

      The answer is in your last line.

  87. Effie Xanos March 17, 2012, 9:56 pm

    Since none of the previous medications increassed my bone density my doctor put me on Prolia and I already had 3 injections .. I am due for the
    4th the end of March and after six months I suppose to have a bone density
    test to see if any improvement happened.. I don’t experience any unusual
    back of arm pains beside the arthritis I have inherited from my mother
    and that happens only when the seasons change…Of course I am nervous about the new Prolia medication.. I have bought the “save our bones ” book and read
    it.. due to chronic IBS can’t follow exactly the diet but I try to eat
    the veggies and fruits which don’t aggrevate the situation.. big dilemma I have
    can’t go back to Fosamax and the likes since they didn’t help , can’t follow 100% the healthy diet due to IBS .. what would you do in my situation?? Another thing, since I stopped taking hormones after the big scare
    in early 2000 I suffer from hot flashes and I am in my 70’s!!



    • Jose L Suescun November 4, 2012, 2:37 am

      If you can not follow Vivian’s diet properly, add Ultimate Bone Support from Advanced Bionutritionals. Find the company in the internet.

  88. RealityCheckforVivian March 7, 2012, 10:42 pm

    Vivian most of your repsonses ask people to buy your “bone health” program.
    This site seems more like a sales pitch than a service to patients.

    For someone who claims to be science based you sure do present a skewed version of the data, so as to reinforce your costly program.

    You mention several side effects for Prolia but never once do you list the incidences of these side effect compared to the placebo arm in the trials.

    For instance you list back pain as the number one side effect for Prolia, but you don’t mention that 1347 patient out of nearly 4000 patients experince that on Prolia, and 1340 patient in nearly 4000 patients on placebo (inactive drug) experienced back pain. Thats a difference of 7 patients in a 3 year trial of almost 8000 patients. Had you mentioned the incidences most people would agree that back pain would be the least of their concerns.

    There is also a difference between what a side effect is and what an adverse event is, but I don’t expect you to know the differen becaue you are not a doctor you just play one on the internet… sell books.

    Shame on you for manipulating innocent women lookng for some real help and guidance, all to make a buck.

    There are pros and cons to all things.
    Work with you doctor to figure out if the benefits out weigh the risks of any therapy.

    If Vivian really cared she would not be pushing her program at every possible opportunity.

    • Mary Ellen Smith September 26, 2012, 2:10 pm

      are you male or female and are you a doctor?

    • j holsten June 14, 2012, 4:21 pm

      Are you affiliated with Prolia in ANY way?

    • Observer March 28, 2012, 2:44 am

      It appears that you have fallen victim to the usual trap that the pharma companies set for all of us.
      Do you know that most of the trials on medications are done by the same companies that manufacture the drug or are assigned to “independant” firms who act according to the wishes of their employer? Why do they do that since it is known to many people? But to clowd the picture ofcoarse. A clowded picture is better than a negative one. And secondly to cast doubt in to the minds of the ones that know what goes on behind the scenes.

  89. WILL HAYMES January 30, 2012, 9:10 pm

    Not really sure why so many people would consider anything from this site of value. The credentials of the author either imply Masters of Arts or Medical Assisistant-neither of these gives her any credibility or accountability to what is written.. The white lab coat would be to convince you she is in the medical field. SHAM! This is a scam to sell books. Listen to your doctor!! He or she went to school, endured a residency, passed a certification and is most importantly in practice.

    • Ed Murfin April 14, 2012, 2:57 pm

      In the UK, Will, if one visits the hospital to consult with a nutritionist, you will be talking to a man or woman wearing a white coverall. They are not pretending to be a doc. The garment is a hygienic and convenient way to be identified readily, and help reduce pathogen dispersal by inhibiting the dispersion of pathogens picked up by workaday garments on the way to their job.

      Vivian claims to be a qualified nutritionist and I’ve seen no reason to disbelieve her. She always includes references and invites her readers to check them out themselves. I always do, hard work though it can be, and I draw pretty much the same conclusions about the meaning she attributes to them. As for making money – why not? We all need to do that – including the drugs manufacturers, who will stoop to any dishonest interpretations of research results if it increases drug usage and hence profits. I wonder why those who criticise Vivian on the ground of the making money allegation, do not mention the drug companies “profit above all” ethos – very well documented down the years – and accuse the drug companies of similar behaviour?

    • Sherrill March 6, 2012, 9:14 pm

      Will…Vivian has a Masters of Arts degree in Nutritional Sciences and Biochemistry which gives her a lot of knowledge regarding bone density and how our body works. She is not a Medical Assistant as you mention. SC

      • BB July 24, 2012, 2:06 pm

        Go to the NYU website. This degree doesn’t exist. The only MA offered by NYU for nutrition is in Food Studies, which is NOT a science-based degree. Also, NYU does not offer any MA in Biochemistry. In fact, a Biochemistry degree typically is NOT a Master of ARTS degree as an MA doesn’t have the same breadth of science courses.

    • Observer February 6, 2012, 6:13 pm

      This is the type of thinking the system relies on to offer patients very expensive and very ineffective treatments often with a devastating price to pay.
      Listen to your doctor but do not act before you do your utmost to double and treble check his diagnosis.
      Besides, doctors can only offer medical knowlege they have been tought at Medical schools. The pharmaceutical industry has infiltrated the education system. There is plenty of proof to this fact. So what it niaouing on the roof?
      My advice to you if you want to live long is not to place your life in the hands of anyone blindly.

  90. Sarah January 21, 2012, 11:13 pm

    What happened to my comment? I spent a long time writing it.

  91. Jane January 14, 2012, 12:01 am

    After taken Fosamax for 5 years with plenty of calcium (through my diet and supplement) along with vitamin D I still managed to have a significant loss of bone. My endocrinologist prescribed Prolia injection. I did a ton of research and decided to go for it. The injection was absolutely painless and so far I have not had any adverse reactions whatsoever. I am a healthy 65 year old, play tennis, go to the gym 3x week, golf. It sure beat the Fosamax!

  92. Julia Hogue January 4, 2012, 9:43 pm

    I have Osteoporosis and have been thru all the oral drugs with no success. Now I think the doc wants to do reclast or maybe prolea. I am interested in doing something natural. I have been exercising and am not overweight. Have had this since my late forties and am now turning 60 in April.

  93. joann December 29, 2011, 12:02 am

    I wanted to share my thoughts on all the bone testing that our now 85 year old mothers never had access to. I had a bone scan when I was 45. It revealed that I had osteoporosis. My entire family mourned my active life stlye loss. My mother kept telling me that I did not have it, she just would not believe that even though the equipment showed the results. She kept telling me that women have been walking around without the fancy testing machines and they were all mostly fine. It was not until the birth of the dexa scan that we are all running around crazy. Well 2 years after my first testing I was retested and the center told me they made a mistake. I did not have a severe case because they rated me on a males scale not a womens rating(they thought I was Jo not Joann),instead I had osteopina.I celebrated and went out and bought a mountain bike! Since then I have taken fosomox, for a short period of 6 months, only to break the small bones in my body 3 x in the last 3 years…small bones are not subjected to osteporosis.When I mentioned this to my doctor she said they have had that happen to many of their fosmox patients (and related simuliar drugs). She suggested Prolia but after reading these posts I would much rather have a broken hip than be in pain all the time. Sounds stupid to say but we don’t know if a thin bone is going to break, there is just not enough studies with the dexa scan to tell that. Maybe I was born with osteopina? Everyone should be tested at 22 to know what your true bone base line is. Just like blood pressure some people have low pressure so when theirs is reading normal it really is high for them..everyone is different.So with that at the age of 57 I’m going to enjoy another year of skiing!

    • Observer February 6, 2012, 6:30 pm

      You should listen to your mother. She was lucky to have lived before the invention of the fancy medical machinery because nobody could direct her to use what is offered for osteoporosis today.
      Also please note that osteopenia is not a decease. It is merely a way to increase the use of bisphosphonates and make more profits. Lastly, it is true that osteoporosis drugs do increase bone density but what has been observed in several trials is that they also make the bones more brittle and this is why people on osteoporosis drugs have a higher number of bone fractures than people on no such drugs. Please correct me but isn’t the reason for taking Osteoporosis drugs to avoid fructures? Think about it.

  94. Jane December 25, 2011, 11:44 pm

    Does anyone have anything good to say about Prolia. My doctor has recommended that I receive the injection because Fosamax didn’t work after 5 years. I am 65 with T scores of -2.9.

    • caren August 4, 2012, 6:29 am

      today i received my 2nd prolia injection. the first one took very well. though with this injection i am having severe headaches.for some reason i could not do the fosamax, so for 3 years i did the reclastinfusion, which caused many side effects, nausea, awful headaches…flu like symtoms. having only my 2nd injection of prolia, i can only say that for me, the side effects were much milder and shorter than taking the reclast infusions. my t-scores are -3.5.

    • Jean June 24, 2012, 9:57 am

      Nothing good to say about it.. I have been taking Protos and had side effects as stated in numerous comments including irregular heart beats. My Doctor wants to put me on the two yearly injections but after reading up on the side effects of that I will say no thank you I have had enough of side effects from the Protos.

    • veronica June 14, 2012, 4:30 pm


  95. Carol H December 1, 2011, 9:55 pm

    I was just disgnosed with sever osteoporosis,in mylower back my numbers are -4.7 very bad from what I am told. My doctor prescribed Prolia, i have been doing my reserach on this new drug and it has too many side effects to be safe. What other alternatives do i have. If I start on Boniva and take my calcium and do exercise will that be enough. I dont wan to end up in a wheelchair or with a broken hip I am only 60 years old. help.

  96. Jenny December 1, 2011, 12:38 pm

    I have been on Actonel therapy for the past 4 years. I had a bone density test taken after taking Actonel for 1 year and it showed a 4% increase in both my hip and spine bone density (I had osteopaenia). So, for the next 3 years, I took Actonel faithfully. Then on October 15th of this year, I had a follow-up bone density test. It showed that the bone density in my spine had decreased (instead of increased!) and that I now have osteoporosis. We don’t know when the Actonel stopped working, and I’m going to go have blood work done this weekend to rule out possible secondary causes for the osteoporosis (other than the fact that I’m post-menopausal). Here’s my problem. My endocrinologist has told me to stop taking Actonel and to start taking Prolia. He made it sound attractive, and I was going to have the injection … until I did a search on the possible side effects. Even the Prolia website takes about the possible side effects … pretty well on every single web page on their website! I guess that they have done this to make certain that everyone knows what “could” happen. So, now I don’t know what to do. I don’t want my bone density to get worse, but I’m rather frightened to take a drug that could cause infectious endocarditis (I have mitral valve prolaps to begin with!). Help. Any suggestions?

    • Vivian Goldschmidt, MA December 4, 2011, 4:35 pm

      Jenny, my suggestion would be to take a close look at the issues with osteoporosis medications by reading the article in the “Drugs” section on this site, and to check out the Save Our Bones Program, which thousands of our members have used to regain their bone health. You can get more info about the program at

  97. Effie Xanos November 7, 2011, 9:49 am

    I am 72 years old with a family history of osteopenia/osteoporosis .. I have been on hormone therapy for almost 8 years and then on Fosamax for another 9 years.. my bone density scans showed osteoporosis in the spine and hip
    and I have lost 2 and 1/2 inches from my spine..last year on September I had my first Prolia injection and this October my third , my doctor wants me to have one more in April and then have a bone density test again to see if there is any imrovement in my bones.. I am a very active person, I walk 2 miles a day, do yoga, lift weights and try my best to eat right.. I have IBS and it’s difficult for me to be on the diet I read in the ” save your bones ” book I have bought.. I can only have small amounts of certain veggies daily with fruits.. I don’t eat red meat at all .. some chicken once or twice a week and I take 4 omega-3 capsules a day… I have family history of arthritis and chronic insomnia and fatique.. I have noticed that for the past year my seasonal allergies last longer and my colds never leave me and of course i am always tired .. I would appreciate any advice you can give me ..

    Thank you,


    Effie Xanos

    • Observer February 6, 2012, 6:42 pm

      Dear Effie, if after taking Fossamax for nine whole years left you in the condition you describe isn’t it proof enough of the effectivenes of such drugs? Results speak for themselves. I am not a doctor but from what I read about osteoporosis I would not touch any of them, especially the more recent very expensive versions. Believe me I wish I was in your condition at 72.
      Best of luck and remember “it is YOUR life”.

  98. Kathy Anderson October 11, 2011, 3:01 pm

    I have been battling severe osteoporosis since the yr.2000. I went through early menopause and was placed on Fosamax when it first came out as a daily pill. My T scores went up and down over a 10 yr. period and ened up just as low after ten years as it was before I started taking the drug. My original T score was -3.3 at age 49. At age 61 my T score 3.5. I took myself off the drug (I also tried Actenal for a year with no good response)and was using HRT to support my bones,plus weight bearing exercising and diet,and supplements.This summer I developed uterine cancer (endometrial) and my bone Dr. wants me to try Prolia. My oncologist wants me to stay on the estrogen( I had a complete hysterectomy in Aug.I don’t know what to do. After reading the info on Prolia, I am scared to death to try it,but am also afraid the estrogen will cause more cancer if there is a microscopic cell stil inside of me. My cancer stage was 1A. What do you think I should do? I feel like I am between a rock and a hard place!

    • Denosumab works October 16, 2011, 8:57 am

      Kathy.. I have been on Prolia for almost 5 years with no side effects at all. Im a 31 yr old male and have taken it for lung tumors. My tumors have not grown in five years and no side effects, so i would say go for it! Its an amazing break thru in my opinion, but like this article says, its a numbers game. Good Luck to you.

      • Kate October 26, 2011, 12:01 pm

        Which country are you in? I live in Canada and it was only approved last year. I have been prescribed Prolia but still deciding whether to take it.

  99. Gloria Carter September 27, 2011, 1:19 pm

    In years past I have taken Fosamax, then Boniva which caused many of the same problem as those listed above……muscle aches and pain etc…..since I am having back issues I couldn’t figure out what was going on. I took myself off the Boniva and 2 months later I was pretty much pain free. Went back to the Dr for my annual checkup and he indicated that Prolia was for me. I had the injection at the end of August and in a short period of time all of the aches and pains are back even worse than before. My questions is how long does it take to get this our of your system….and…does it cause hot flashes?


    • Observer February 7, 2012, 4:00 am

      Dear Gloria,
      if you bothered to do some basic research on Prolia or even if you bothered to read their leaflet (if the doctor allowed you ) you would have read some of the common side effects:
      Backpain,increased cholesterol,skeletal pain,arm and leg pains, pangreatitis,bladder infections,ear infections,skin infections,rash, eczema,endocarditis,severe jaw bone problems and to top it all a warning by the maker that “it may cause unusual fractures”. It is obvious that one does not get all the above by taking the drug but I challenge you to chose just one or two having in mind the maker’s warning above and decide whether the drug is for you.
      Concerning your question, I suggest you ask the smart doctor who put you on that lethal cocktail without obviously giving you the information that you were entitled.

      • Name April 13, 2012, 2:39 pm

        A lot of prescription drugs have side effects that make you feel like the treatment is worse than the disease you already have.
        Lipitor for example, has major potential side effects but it is one of the most prescribed and best selling drugs. It does work for the condition it is intended to treat.
        Only time will tell if Prolia is safe enough to take the risk.
        I am skeptical of people who try to reach conclusions too early.

  100. GLORIA ANGELES September 15, 2011, 4:23 pm


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