How The Master Antioxidant Protects Your Liver And Rejuvenates Your Bones - Save Our Bones

I always find the interconnected nature of our bodies to be extremely intriguing. If one aspect or system is not functioning correctly, it affects the rest of the body, including your bones.

Today’s post reveals a perfect example of this phenomenon.

It has to do with glutathione, the Master Antioxidant that Savers already know protects bones from oxidative damage. But what’s rarely mentioned is that glutathione is also crucial for the proper functioning of a vital organ that plays a major role on your bone health.

And that’s today’s fascinating topic.

Your Liver Is Vital To The Health Of Your Bones

Your bones can’t rejuvenate and flourish if your liver is not functioning well. The liver is one of the primary detoxification organs and in this modern world, it’s inevitable that your system is bombarded with chemicals and other acidifying toxins every day. Your liver filters these harmful substances out of your blood and protects your bones from toxic substances.

But your liver is important in lesser-known but very crucial ways. In fact, it manufactures and synthesizes certain nutrients and compounds that are essential for bone mineralization and integrity.

An enzyme called Bone Alkaline Phosphatase (also known as isoenzyme ALP-2) is manufactured in your liver. This enzyme has a pH of 10, so it’s extremely alkaline. It helps osteoblasts build bone, and Vitamin D performance depends on it.

Speaking of Vitamin D, Savers know how vital this fat-soluble vitamin is to bone health, and it’s made in the liver. More correctly, the precursor to Vitamin D is manufactured in the liver. Then, when your skin is exposed to sunlight, this precursor is converted to Vitamin D3. Then it’s back to the liver where the D3 is synthesized into a hormone.

And that’s not all. Vitamin K, the seldom-mentioned by crucial vitamin for bone building, is a cofactor in a calcium-binding process called carboxylation, which takes place in your liver. And Vitamin K works in synergy with Vitamin D3 to regulate osteoclast production.

So it’s absolutely crucial that your liver be in top shape if you want to reclaim younger, healthier bones.

The Seldom-Mentioned Connection Between Glutathione And Your Liver

Glutathione protects your liver, and research shows that it “plays a key role in the liver in detoxification reactions.”1 More research sheds light on how glutathione aids the liver.

Glutathione actually exists in two forms, the most prominent one being GSH (thiol-reduced), which is found in nearly every cell in the body. GSH’s main function is to detoxify xenobiotics and the byproducts of their metabolism.2 A xenobiotic is an unnatural chemical substance that is foreign to the body, including prescription drugs. Interestingly, the liver contains the highest amount of GSH of any organ in the body.

Liver cells have the ability to convert an amino acid called methionine into cysteine, which is a precursor of glutathione.

According to a 2011 study, “in the liver, major factors that determine the availability of cysteine are diet, membrane transport activities of the three sulfur amino acids cysteine, cystine and methionine, and the conversion of methionine to cysteine via the trans-sulfuration pathway.”3

We’re going to discuss more about the role of diet in glutathione levels later, but first I want to share some incredible discoveries about this antioxidant as it relates to aging.

Research Shows Glutathione Prolongs Your Life

Amazingly, recent studies clearly show a correlation between high levels of glutathione activity and longevity.

Building on a 1998 study that showed higher levels of active glutathione in centenarians (individuals aged between 100 and 105) as compared to those who were 60-79 years of age.4

Four years later, researchers revisited this subject and evaluated 87 healthy women aged 60 to 103. Their conclusion after 5 years of observation: high concentrations of glutathione in the blood are characteristic of long-lived women.5

Of course, learning how miraculous this antioxidant is begs the question…

How Can I Get More Glutathione In My System?

Simply put, glutathione levels can be increased by the intake of certain nutrients and by regular exercise. I’ll explain.

Your body manufactures glutathione, but it needs certain nutrients to do it. If you’re following the Osteoporosis Reversal Program, you’re already ahead of the game. Let’s take a look at some of the Program’s Foundation Supplements that specifically aid the liver.

  • B Vitamins: folate, B6, and B12 are vital for your body’s production of glutathione. Called “methylation nutrients,” these vitamins play a key role in the recycling and renewing of glutathione.
  • Vitamin C, a popular supplement during cold and flu season, works in its antioxidant capacity to recycle glutathione.
  • Magnesium, a mineral that’s on par with calcium in its importance to bone health, is part of glutathione synthesase, an enzyme that plays a role in the making of glutathione.

In addition, there are Foundation Foods rich in these and other nutrients that boost glutathione production:

I know that Savers are already doing more to boost their glutathione levels, such as…

Engaging In Regular Exercise

When researchers studied glutathione levels of individuals who had engaged in exercise, they found that their levels of the Master Antioxidant had increased.6 The key is moderate, regular exercise rather than exercise that is intense and strenuous.

Boost Your Liver Health For Optimal Glutathione Levels And To Build Your Bones Faster!

As you take in these vital nutrients and exercise regularly, you’ll want to make sure your liver is cleansed of toxins to make the most of these Master Antioxidant building blocks and to accelerate your bone building results.

It’s not as difficult as you think. In fact, it’s not difficult at all. With the Osteoporosis Fresh Start Cleanse: The 7 Day Bone Building Accelerator, you’ll discover that your liver (and therefore your entire body) can undergo a thorough cleanse in 6 steps over just 7 days.

Steps 1-4 involve cleansing with key foods, beverages, and breathing techniques. And Step 5 is perhaps the easiest: Cleanse by Avoiding. You’re given a list of substances to steer clear of during the cleanse so your liver doesn’t have to work to process them.

I invite you to read more about this amazing cleanse that’s so easy yet highly effective. Please click here to learn more.

Till next time,


1 Kaplowitz, N. “The importance and regulation of hepatic glutathione.” Yale Journal of Biology and Medicine. Nov-Dec. 1981. 54(6): 497-502. Web.

2 Lu, Shelly C. “Regulation of Glutathione Synthesis.” Molecular Aspects of Medicine. 2009; 30(1-2): 42-59. Web.

3 Lu, Shelly C. “Regulation of hepatic glutathione synthesis: current concepts and controversies.” The Journal of the Federation of American Societies for Experimental Biology. July 1999. Vol 13 no 10 1169-1183. Web.

4 Andersen, H. R., “Lower Activity of Superoxide Dismutase and High Activity of Glutathione Reductase in Erythrocytes From Centenarians,” Age and Ageing, 1998; 27:643– 8.

5 Lang, C. A., et al. “High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years.” J Lab Clin Med. 2002 Dec; 140(6):380–1.

6 Dufaux, B., “Blood Glutathione Status Following Distance Running,” International Journal of Sports Medicine, 1997;18(2): 89–93.

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Comments on this article are closed.

  1. Cathy

    Hi Vivian, I just ordered your book on building bones. I was just diagnosed with psoriatic arthritis instead of anklosing spondylitis and I have 6 compression fractures and osteoporosis. Your book is for building bones but is there any foods in there that’s going to make my arthritis worse. I was reading testimonies on eating tomatoes that they are great for building bones but not for arthritis. Could you please comment on this. Thank you Cathy

  2. Marlene Villar

    Dear Vivian,
    An excellent article. Thank you very much for sharing,
    Vivian. I truly appreciate everything you’re doing to
    help equip us with knowledge and choose to apply them
    according to each individual needs.
    Have a wonderful day and take care always. Marlene

  3. Barbara Montgomery

    Have you ever heard of the calcium suppliment, EZorb? If so, what do you think about it?

  4. shula

    Thanks !

  5. Laura Deyarmin

    I thought that dairy was off your list of items to injest. Isn’t whey a dairy by-product?

    • Vivian Goldschmidt, MA

      Actually, Laura, no foods are “off the list” completely. 🙂 It’s a matter of applying the knowledge about dairy products and making use of them in a balanced way. Whey is a byproduct of the dairy fermentation process. Here is an excerpt from one of my posts on whey:

      “Milk has two main sources of protein: cassein and whey, and it’s the alkalizing whey that contains lactoferrin. So you don’t need to drink milk in order to get the benefits of lactoferrin. In fact, the best way to get lactoferrin is by drinking a whey protein shake with almond milk, another milk substitute, or even water.”

      You can read the full post here:

      Keep asking questions!

  6. Helen S.

    Another wonderful, and wonderfully researched and articulated, article. Another gift on how we can get ourselves deeply healthy – right down to our bones – and stay that way. Thank you, Vivian.

    • Vivian Goldschmidt, MA

      You are most welcome, Helen! I hope you will continue to read and participate. 🙂

  7. Ben

    Great articel and very informative. We need these special information beased on special knowledge of how our body work with the help of the vitmains, minerals, enzymes, co-enzymes and co-factors. Thanks to the welath of information from modern research which throws more light on the application of such knowledge. Thanks Vivan for sharing.

    • Vivian Goldschmidt, MA

      You are welcome, Ben! I never cease to be amazed at the level of detail on which our bodies work…it’s simply incredible!

  8. Jeanie

    Following a car accident 5months ago I have been unable to do do anything and have lots of pain and inflammation on hip and knee. I am having Epsom salt baths (magnesium sulfate) putting 2 cups in each bath as I have been told this will reduce the inflammation and introduce magnesium into my body healthily. Is this correct Vivian.

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