One of my primary commitments is to keep you up-to-date on the latest osteoporosis news, including the most recent osteoporosis research and drugs. Today you’ll read about a newly discovered side effect of a blockbuster drug and the mysterious delay for approval application of what could become the next best-selling osteoporosis drug.

So let’s get started…

Plavix Alert

In addition to the already known, dangerous side effects of the very popular blood thinner Plavix, a new study has surprised researchers with its results.The study, conducted by Danish researchers, showed that Plavix increased osteoporosis risk by 50 percent in those taking the drug.

Researchers included in the study other blood thinners that have the same active ingredient: clopidogrel, so it seems that this substance is the culprit.

Increased Osteoporosis Risk is One of Many Side Effects of Plavix

Compared to the lengthy list of known side effects of Plavix, the increased risk of osteoporosis just discovered can be considered one of the least dangerous. Other side effects include hemorrhage, such as bleeding under the skin, nosebleeds, and brain hemorrhage.

And ironically, while the drug is prescribed to prevent recurring heart attacks and strokes, Plavix affects the cardiovascular system. Side effects such as heart failure, chest pain, edema, and hypertension in addition to syncope, palpitations, and atrial fibrillation are also included in the long list of side effects.

And it gets worse. As its manufacturer warns, “Plavix can cause bleeding which can be serious and can sometimes lead to death.”1

The nervous system is not immune to the side effects of Plavix either – dizziness and headaches can occur as a result of taking Plavix. And last but not least, insomnia and back pain have also been reported.

News Excerpt

“Danish researchers surprisingly conclude that the blood-thinning drug may increase the risk of patients developing osteoporosis – also known as brittle bone disease – and thus risk breaking e.g. their spine, hips or wrists.

‘It appears that the risk of developing osteoporosis increases by around 50 percent, primarily for people who have been taking the drug for a year or longer,’ says Niklas Rye Jørgensen, chief physician at Glostrup Hospital. ‘This is interesting because Plavix has been a “blockbuster drug” for some years now, where it’s been number one and two on the list of best-selling drugs in the world, so many people are affected. And the harmful effect may be quite considerable.’ …

Together with Danish and international colleagues, Jørgensen has examined 77,000 Danish patients, who in the period 1998-2008 were treated with Plavix or other drugs which, like Plavix, contain the active substance clopidogrel. … After having adjusted for other factors that may affect the risk of osteoporosis, the researchers were left with something that looks like a clear conclusion: patients on clopidogrel have a far greater incidence of broken hips and wrists as well as spinal collapse than those who have never taken clopidogrel.” 2

Odanacatib Alert

Merck has just announced that the application for regulatory approval of its newest osteoporosis drug will be delayed. The reason for this remains a mystery, but based on the secrecy about the negative side effects of the latest Phase III trial, it is likely that there are some nefarious side effects to this drug that, at least for now, Merck has chosen not to reveal.

Odanacatib is not a bisphosphonate; it works via a different mechanism, but the effect is essentially the same. Odanacatib blocks an enzyme called cathespin K that’s responsible for the healthy breakdown and resorption of bone. If you got the Osteoporosis Reversal Program, you have a good understanding of bone remodeling, which is the process by which old bone is broken down and replaced with new bone.

News Excerpt

“Merck said on Friday that it would delay seeking approval for an experimental osteoporosis drug, an announcement that helped send the company’s shares down 3 percent on the same day it announced its fourth-quarter earnings for 2012.

Company executives told analysts in a conference call Friday morning that Merck was delaying its application for the drug, odanacatib, because it is seeking additional data from a clinical trial. But they said they remained confident in the drug’s ultimate chances for approval and would submit their application in 2014.” 3

There’s No Such Thing as a 100% Safe Osteoporosis Drug

It’s more than likely that Big Pharma will pull off yet another profitable deception, obtaining approval and raking in huge profits before dangerous new side effects are discovered in the longer term.

The bottom line is that there never has been and never will be an osteoporosis drug that’s safe. While the methods and chemicals differ, at the most basic level all of these drugs are designed to counteract and thwart a natural process: bone remodeling. And the effects of these drugs are far-reaching and often devastating.

Fortunately, There is a 100% Safe Alternative to Treat Osteoporosis

The Osteoporosis Reversal Program is 100% safe and 100% natural, scientifically-proven and doctor-approved. And it has changed lives for the better in great part by giving community members full control of their bone health with absolutely no risk of dangerous side effects.

Essentially, the Osteoporosis Reversal Program is a nutritional, lifestyle, and exercise plan designed to improve bone density naturally, and to help you build strong and healthy bones. And there are no drugs involved!

Till next time,

References

1 http://products.sanofi.us/plavix/plavix.html
2 Hoffman, Thomas. “Bestseller drug may cause osteoporosis.” Science Nordic. January 31, 2013. Web. http://sciencenordic.com/bestseller-drug-may-cause-osteoporosis
3 Thomas, Katie. “Merck Delays Osteoporosis Drug.” The New York Times. February 1, 2013. Web. http://www.nytimes.com/2013/02/02/business/merck-delays-osteoporosis-drug.html?_r=2&

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63 comments. Leave Yours Now →
  1. Debbie Reis February 22, 2013, 1:23 pm

    Its not a big surprise the drug companys want to keep the people sick and delay the hope of ever finding some drug that would actually help. Its all about the big dollar. What a shame.

  2. fe February 21, 2013, 7:04 pm

    Hello Dr. Vivian Goldschmidt , i would asked you? my son was very had alergy on almost food he ate , what possible to do to increase his bone density , and me s breast cancer survivor for at least 10 years ago now. Is that sugar can increases the growth of cancer cell ? what really the remedy of food can we be eaten ? we are living in country where food are hard to find especially fruits? .

    • Merle Murad-Sampson February 27, 2013, 3:35 pm

      Thank you Vivian for your prompt research You are on top of things…I am so glad I found you.
      You will not be popular with the drug company because you are exposing them… Thanks again I love you…..Keep up the good work…

  3. Hannah Tipper February 19, 2013, 3:34 am

    Dear Vivian, Have you found out anything about the drug Calcitrol yet? I am trying to be patient. Please let me know. Thank you for all of your work for us, Hannah

  4. bea mowry February 15, 2013, 7:02 pm

    hi Vivian I usually have a smoothie in the morning I have one made with 5 fruitsand I put kale and spinish in it also is this to much fruit you said 80/20 am I doing it right please ans. my question thank you so much. bea

  5. Leslie (MS. L.) February 15, 2013, 3:20 pm

    Hi! Vivian,

    Thank You VERY MUCH For Keeping Us Up To Date On The Latest Things To Help Us SAVE OUR BONES!

    I Hope You Had A Wonderful Valentine’s Day!

    LOVE, LESLIE (MS. L.)

  6. Jane Tushingham February 14, 2013, 9:15 pm

    My condition is at the osteopenia stage and I’m hoping to prevent worsening to osteoporosis. I don’t want to take any drugs and so my doctor recommended doing resistance exercises for my legs on equipment at the Y. I also go there for circuit interval training (step aerobics and weight training) in addition to running 2-3 miles several times a week. I would like to be added to your email list in the future.
    Your website was recommended by another person already receiving your info.
    Thank you.
    Jane Tushingham

  7. Char February 14, 2013, 8:52 pm

    Once you have this, can you ever get back to where you need to be?

  8. cornell d. February 14, 2013, 5:47 pm

    thank you for being there for us uninformed guinea pigs .those drug makers are truely worst than street dealers when it comes to how they make their money and not caring for the public.and thanks again for being you!!!!!

  9. a. touba February 14, 2013, 4:21 pm

    what do you suggest a person that needs a bloodthinner should do?

    • joyce April 15, 2013, 8:49 pm

      I would also like to know what to do instead of taking Plavix.I do follow the Save Your Bones programme.
      I had something the doctor called a TIA and that is when they put me on Plavix.

    • marie lundy February 14, 2013, 6:23 pm

      what is a avatar?

    • marie lundy February 14, 2013, 6:22 pm

      i take 7and ahalf milligrams of warfrin a day 20 milligrams of lisisnopri forhigh blood pressure a day along with 10 milligrams of zetia a day for high colestrol.i have severe pain in both my legs please tell me if these meds are causing this pain , and also what problems if any are these drugs causing my body.

  10. Jeanine February 14, 2013, 2:59 pm

    This, as always, is good information. However, what does a person do who has stents and needs to take plavix? Is there a way to counteract the ill affects of the drug?

    • Rosemary February 15, 2013, 9:19 am

      Good luck to those of us who have to take Plavix. Taking the drug is a must. Combat those side effects with extra care of following a healthy bone diet is all I will do. We’re stuck. I’ll be upping my D3 to 5000 mcg’s. Taking it with K-2 and an extra serving of yogurt. More exercise, I guess.

  11. june mathers February 14, 2013, 6:12 am

    can any one sugest a cheaper option of getting Ostiocare into Australia? The shipping cost from America make it impossible

  12. Betty Schutz February 12, 2013, 7:55 pm

    I was told that vitamin k-2 is not good to take. It is a blood thickener and not good for your heart. I would like to know if that is true.

    Thank you,
    Betty Schutz

    • Jose L. Suescun February 13, 2013, 3:37 am

      Betty: You have to take H2, if you want the Calcium to go to your bones, instead you arterial valls

      • Betty Schutz February 14, 2013, 12:14 pm

        Jose, thank you for the information a vitamin k-2. Do you take it? Please let me know.

  13. Gay Cullen February 12, 2013, 2:20 am

    Hi Vivian
    I have been diagnosed with AF and the doctor has recommended that I take Warfarin. As this concerns me greatly, do you know of any natural supplements that I could take that would have the same effect or how I could go about controlling it? Many thanks for your continued information. It is really appreciated. Kind regards, Gay

    • jim February 14, 2013, 3:48 am

      Fishoil Omega 3 has a blood-thinning effect and it’s good for your heart !
      Probably a good idea to have it monitored to get the right amount for your situation.

    • Jose L. Suescun February 13, 2013, 3:53 am

      Gay: Take Nattokinase instead. Requires no lab control and decreases the blood VISCOSITY. Its increased index carries the most risk for cardiovascular disease and stroke.

  14. Hannah Tipper February 12, 2013, 1:01 am

    Dear Vivian,thank you for all of the good infomation you have given us. I was on several meds over the years, but when my Indocrinologist wanted me to have Reclast, I refused after reading about what you had said and I got on several sites about it and it scared me to death. I told him NO. Now he is trying to push Calcitrol on me. I had the prescription filled and have not taken the first one. That was 6 months ago. I have to go and see him next week and he will probably have a fit. I have MS and a spinal cord problem, diabetes, chronic thyroiditis, PAD, bad reflux and have to take Prevacid which I know is not good for my Osteoporisis, and also Ranitine for nocturnal reflux which I don’t take half of the time. Then I have to take Tramadol for my leg pain and knee pain and Diazpam for the terrible cramps in my feet. They have been cramping since I was in my 20s and I will be 72 on the 15th of this month. I have been taking the Diazepam since 1998 after my back surgery to try to correct my spinal cord problem. It did decrease the pain, but that is all. I walked on a walker for 5 years and it gave me Ratator-Cuff problems in both shoulders. The surgeon will not operate on me, but I am fixing to go and get x-rays and a shot in my right arm. The last time I went for Physical Therapy, they told me that I was not strong enough for it again. so I feel at a loss right now. I am in a wheel chair now, but I can do everything personal for myself, and I can load tha empty the dishwasher and do a few things like that. We are fortuanate that we can have a sweet girl that cleans the house every other week. My hisband has a bad back and has several surgeries. They did not hurt him, but nothing has helped either. He has to have some one do the yard work and he was such a hard worker and does so much for me. He is my Prince ,and I tell my friends I believe he is an angel God gave me on this earth. He is a special person and I thank God for him everyday. He has to put my wheelchair in and out of the car if we go off. Well, I know I have taken up too much time. If there is anyone on this site that needs prayer, I am a prayer warrior so I would love ot pray for anyone that needs prayer. Jesus is no.1 in my life. Love to all, Hannah

    • Diane Woodall February 18, 2013, 12:31 am

      Your life sounds very complicated. Dr. Hyman’s book Sugar Solution have some sound advice for lowering sugar and I have found my leg aches disappeared when I gave up wheat and sugar. There are some interesting facts out there about side affects of wheat. Good luck and God bless.

  15. Alice Lawson February 11, 2013, 11:03 pm

    What is your opinion of taking silica and MSM in place of a calcium supplement?

    • Alice Lawson February 13, 2013, 1:21 pm

      What is your opinion of taking silica and MSM to replace calcium supplements?

  16. Helen February 11, 2013, 10:27 pm

    Thanks again for all updates, Vivian! Very informative and helpful!

  17. Tanialee Bowman February 11, 2013, 9:07 pm

    lth but the recent issue of “Woman’s World” magazine states that ruby red grapefruit and blood red oranges are extremely good for building bones. What do you think Vivian?

  18. Gee February 11, 2013, 8:41 pm

    Is ‘Osteoporosis Reversal Program’ effective for people with -3.00+ bone density?

  19. EVELYN HUFF February 11, 2013, 7:38 pm

    HAVE YOU PUBLISHED INFORMATION ON FIRBROMILAGIA OR CAN YOU RECOMMEND WHERE I CAN FIND NATURAL HELPS.

    THANK YOU,
    EVELYN

    • Jose L. Suescun February 13, 2013, 2:46 am

      Evelyn: Fibromyalgia is being treated successfully since the late 1990’s, but needs a maintenance treatment for life.Do you have it?. You can email me to fibrocan@hotmail.com

  20. GAIL SILVERMAN February 11, 2013, 6:17 pm

    i have read the book but am having trouble figuring out how to make my ph urine more alkaline? I eat a lot of veggies but also eat popcorn every day as a snack- should i drink alkaline water? could my hashimoto thyroidistis be a culprit even though I am not on any medication yet

  21. TTunno February 11, 2013, 2:27 pm

    Is Trueosteo considered a supplement vs a drug? I was wondering since it was an advertisement on your website.

    • Vivian Goldschmidt, MA February 11, 2013, 6:54 pm

      TrueOsteo is a calcium supplement. It’s not a drug. 🙂

  22. francis February 11, 2013, 2:20 pm

    Nattokinase is what everyone should be using for blood thining. check it out.

  23. Debbie February 11, 2013, 1:30 pm

    The only reason I would allow them to give me reclast is because I have stage II breast cancer. They told me the biophosphates help keep the cancer cells from invaiding the bones if cancer cells were still in my body. The bones do become hard and I guess that proves it.

    I surely would not be taking it if not for the breast cancer. I guess I have to treat my cancer first and unfortunately my bones second. What a choice.

    • Jose L. Suescun February 13, 2013, 3:02 am

      Debbie: My answer to Evelyn went to you, due to an error. Throw the biphosphonates out of the window and get a real and very simple cancer killer with 80% success rate. It is too late now and too long to explain here. If interested, email me to fibrocan@hotmail.com. I can see you have Coral helping you too

    • Jose L. Suescun February 13, 2013, 2:49 am

      Evelyn: Fibromyalgia is being treated successfully since the late 1990’s, but needs a maintenance treatment for life.Do you have it?. You can email me to fibrocan@hotmail.com

    • Coral February 11, 2013, 4:10 pm

      Hi Debbie, I have some very exciting info i would love to share with you regarding your cancer.
      Please email me on coral.vorster@gmail.com so i can send you the info.

  24. Gail Diederich February 11, 2013, 11:57 am

    My DEXA scan scores over 4 years are living proof that the “drugs” are NOT needed and improved bone scans can be achieved with vigilant efforts of taking AlgaeCal and Strontium per the recommendation AND participating diligently in physical exercise that includes free weights. No one, absolutely NO ONE, could have convinced me to take the damaging drugs that tout their promises of saving our bones, after I educated myself on how bones restructure themselves and what my responsibility was in the process of taking care of my bones. I’m 64 and have moved from borderline osteopenia/osteoperosis to barely borderline/almost normal range with my reading. More importantly, the strength I feel and what I am able to accomplish physically is mind boggling, to me, my family and my doctor who has nothing but huge words of praise for AlgaeCal. During the 10 days following my recent 64th birthday I walked 6.4 miles, swam .64 mile and bicycled 64 miles. Yes, I’m driven and determined but what I did can be accomplished by anyone who is willing to assume responsibilty of their health and not simply succumb to saying “It’s in the hands of the doctor” and reach for the next prescriptions! Doctor’s are our helpmates when we need them. Our health is up to us as individuals.

    • Vivian Goldschmidt, MA February 11, 2013, 6:54 pm

      Amazing, Gail! Thank you so much for sharing that wonderful testimony of health!

  25. Dorothy February 11, 2013, 11:46 am

    I have your book Save our Bones Program. My knees and hands really hurt with
    osteoporosis. I have an occupational hand type of clay given to me by the hospital. I use it, but I need to know what I can do for the pain. Sometimes I can hardly get up out of the chair. Thanks for all of the research you are doing.

  26. Marie S February 11, 2013, 11:46 am

    Vivian,
    What is your opinion of the effectiveness of ‘Fosteum’. My Dr suggested that I try it before resorting to prescription meds due to the unwanted side effects. I have since moved to another state and my new Dr does not think Fosteum will be beneficial since I am at -2.1 in my spine and wants me to start Boniva asap. Looking forward to your reply.
    Marie

  27. Connie February 11, 2013, 11:11 am

    I love to read all your helpful info. It has changed my life. However, I have such a difficult time maintaining my weight, that I must eat lots of grain based products to keep from losing. If I followed the program as I should, I would lose weight daily. I have a high metabolism, dystonia, osteoporosis, and — I am an elementary school teacher!! Thanks for keeping the info coming! Every bit helps.

    • Betty February 11, 2013, 11:30 am

      I have a weight problem as well and keep losing. When you don’t eat high calorie foods and you are slim naturally, I think I look unwell and friends are asking if I am. What is alkaline with lots of calories?

      • Vivian Goldschmidt, MA February 11, 2013, 6:52 pm

        Dear Betty and Connie,
        You can add more complex carbs that pack calories, such as bananas, grapes, alkalizing beans, green peas, sweet potatoes, potatoes with peel, etc. And you can up the calories of the acidifying foods, such as replacing chicken with beef.

        What also helps is having multiple snacks throughout the day.

        If that doesn’t do it for you, you could try switching to a 70/30 alkaline/acid balance, so as to increase consumption of higher calorie foods (pasta, brown rice, bread, etc.).

        I hope this helps! Have an excellent week, and I hope your students let you have a snack or two, Connie! 🙂

  28. Sharon February 11, 2013, 11:05 am

    Drugs promoted by Big Pharma appear to be more and more frightening. I feel fortunate to have a doctor who believes in a “gentler” approach.

  29. Daljeet Chana February 11, 2013, 9:40 am

    Just wanted to share the following:

    A delicious fruit Olive leaf extract enjoyed in Mediterranean cuisine can fight infections, strengthen your immune system, protect against heart disease, prevent osteoporosis and help you lose weight.

    A recent study published in Osteoporosis International showed that concentrations of oleuropein stimulated the number and activity of osteoblast cells (the cells that are responsible for bone formation). Not only did the compound increase osteoblasts, but it also increased the expression of genes linked to osteoblast production.

    Researchers summarized the results of their findings, stating: “Our data suggest that oleuropein, highly abundant in olive tree products included in the Mediterranean diet, could prevent age-related bone loss and osteoporosis.” Good news for the 75 million around the world who have or are at risk of developing osteoporosis, a condition that results in low bone mass and significantly increases your risk of fractures, particularly of the spine, hips and wrists.

    • Jose L. Suescun February 13, 2013, 3:18 am

      Like cinnamon to control type ll diabetes, olive leaf extract does it too, by reducing the absortion of carbos from the intestines

    • Vivian Goldschmidt, MA February 11, 2013, 9:49 am

      Thank you for sharing that information, Daljeet! The olive is an amazing fruit with many bone-healthy benefits…have you read my blog post on olive oil? You might enjoy it:

      https://saveourbones.com/cook-with-the-oil-your-bones-crave/

      Have a healthy and happy week!

  30. Marilyn February 11, 2013, 9:30 am

    Do you know any one that is taking Alagecal Plus Calcium.If so please comment.Or the best calcium supplement .Thank you.

  31. jose February 11, 2013, 9:10 am

    does someone knows about glaucoma??

  32. Christine Anagnostopoulou February 11, 2013, 9:05 am

    Thank you for your research and information

    this is greatly appreciated__

    Christine Anagnostopoulos

    • Vivian Goldschmidt, MA February 11, 2013, 9:44 am

      You are most welcome, Christine! Thank you for being a member of the Save Our Bones community. 🙂

  33. Patricia Downes February 11, 2013, 5:41 am

    I enjoy reading your comments when you send them to me My osteoarthritis gets worse in my neck I feel as if it is locked then I have the nerve pains that go up into my head

    • Vivian Goldschmidt, MA February 11, 2013, 9:47 am

      Patricia, that sounds quite painful – I am sorry you are experiencing that! Did you know that in some cases, arthritis is caused by too much accumulation of acid residue in the joints? Even if it is caused by something else, arthritis is aggravated by too much acid accumulation. Many in the Save Our Bones community experience relief from arthritis when on the program, because reducing acid residue and bringing the proper acid/alkaline balance to the body is precisely what the Osteoporosis Reversal Program is designed to do. 🙂

      Have a wonderful week!

  34. Nu Ly February 11, 2013, 4:38 am

    I have high blood presure, but I am lucky, I don’t need to take any blood
    thinner. But if my blood was too thick, what should I do? thanks.

    • Jose L. Suescun February 13, 2013, 3:32 am

      Nu Ly: yes, take nattokinase, if you need it in the future. It does not require frequent blood tests, like warfarin does.
      Viscosity has the most risk of developing cardiovascular disease. Very few doctors test for it. My own doctor says that viscosity does not exist!!!. My hypertension went down to normal limits with flaxseed oil.

    • Ivy Chang February 11, 2013, 1:40 pm

      I understand eating garlic and ginger helps thin blood. You may want to try natural foods over any drugs.

    • Julie February 11, 2013, 5:07 am

      Try Nattokinase, a natural blood thinner with no side efects. I am taking it to help COPD, but it also has a thinning effect. I buy it online, it’s not expensive.

      • Jose L. Suescun February 13, 2013, 3:48 am

        Julie:If you get in trouble with your COPD and the secretions choke you, go to an alternative physician to receive IV 35%,food grade, Hydrogen Peroxyde. It will clear your lungs for a while, like nothing else.

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