This month’s Bulletin is full of eye-opening information that I am really excited to share with you.
The use of bisphosphonates is decreasing at a fast rate, as awareness of their dangers becomes widespread.
But the drive to treat osteoporosis with drugs is still alive and well – in fact, a new drug is already in the latter stages of development, and its mechanism of action is truly frightening.
And once again, Savers are ahead of the game in whole-body health – new research shows that a short-term dietary tweak boosts the health and function of many important body systems.
Let’s begin with…
1. Bisphosphonate Use At An All-Time Low
The word is getting out: bisphosphonates are harmful and dangerous, and useless against osteoporosis. Bisphosphonate use has decreased by over 50% in the United States over the last few years.
“Following a decade of steady growth, use of bisphosphonates—medications that are effective for treating osteoporosis—declined in the United States by more than 50% from 2008 to 2012.
The sudden drop seemed to occur after media reports highlighted safety concerns, such as the development of certain fractures that occurred rarely in long-term users, despite the fact that the US Food and Drug Administration and the American Society of Bone and Mineral Research did not recommend any specific safety restrictions on bisphosphonates.”1
The lack of “specific safety restrictions” doesn’t mean the drugs are safe, as the experience of all too many proves. These drugs have been on the market for many years, and they have not suddenly become unsafe; they were always harmful at worst, useless at best. But the sudden drop in their use is largely due to increased awareness of the risks.
Once again, knowledge is empowering – it can even affect the sale and distribution of an entire class of drugs and help many osteoporosis patients avoid their awful side effects.
But of course, drug manufacturers are moving forward in their quest for the perfect osteoporosis drug. Their latest attempt is disturbing…
2. New Compound Alters Genetic Expression Of Stem Cells
In treating insulin resistance in Type 2 diabetics with drugs called thiazolidinediones, scientists began to notice a peculiar side effect: a reduction in the number of bone-producing cells. Thiazolidinediones work by stimulating a protein called Peroxisome proliferator-activated receptor gamma, or PPARy.
So researchers set out to develop a drug that suppresses PPARy with the intent of having the opposite effect: increasing bone-forming cells.
“Peroxisome proliferator-activated receptor gamma (PPARγ) is a receptor present on stem cells, the immature cells from bone marrow that can become different types of cells.
Receptors are protein molecules that react to specific chemical signals, much in the way a lock can be opened by a key.
Stimulation of PPARγ causes the stem cells to turn into adipocytes (fat cells) rather than osteoblasts (the cells involved in bone formation).
A class of drugs called thiazolidinediones, or glitazones, target PPARγ to improve insulin sensitivity for people with type 2 diabetes. A side effect of this drug is that fewer osteoblasts are formed.
A chemical compound called SR1664…partially blocks the receptor, still improving the insulin sensitivity but without reducing the number of stem cells that turn into osteoblasts.
From this, the researchers have developed another chemical compound called SR2595, which stimulates the PPARγ receptor to have the opposite effect, causing the stem cells to turn into osteoblasts.”2
What SR2595 actually does is suppress PPARy’s activity in the body. This is a big red flag.
When you suppress a biologically active compound, you’re in dangerous territory. PPARy has various important roles in the body, regulating the genetic expression of nearly all body tissues, including the heart, colon, kidneys, muscles, pancreas, and spleen. If SR2595 is suppressed, then it stands to reason that these tissues and their attenuating biological processes will be affected.
Gene expression is naturally regulated by the body, and can be influenced by lifestyle choices such as exercise. But introducing a compound that will artificially alter gene expression is a frightening prospect. What other genetic expressions will be altered and skewed in the presence of SR2595?
3. 5-Day Low Calorie/Low Protein Diet Promotes Longevity
Periodic fasting has been shown to have various health benefits, but strict fasting can be challenging and even dangerous.
Professor Valter Longo of the University of Southern California Davis School of Gerontology and director of the USC Longevity Institute, along with his colleagues, did a 3-tiered study on the health effects of periodic fasting. Based on that research, they developed a diet that mimics fasting.
Called the FMD, this new approach has shown startling health benefits, including reduced bone mineral loss.
“In a new study, Longo and his colleagues show that cycles of a four-day low-calorie diet that mimics fasting (FMD) cut visceral belly fat and elevated the number of progenitor and stem cells in several organs of old mice—including the brain, where it boosted neural regeneration and improved learning and memory.
The mouse tests were part of a three-tiered study on periodic fasting's effects—testing yeast, mice and humans—set to be published by Cell Metabolism on June 18. …
Bimonthly cycles that lasted four days of an FMD which started at middle age extended life span, reduced the incidence of cancer, boosted the immune system, reduced inflammatory diseases, slowed bone mineral density loss and improved the cognitive abilities of older mice tracked in the study. The total monthly calorie intake was the same for the FMD and control diet groups, indicating that the effects were not the result of an overall dietary restriction.
In a pilot human trial, three cycles of a similar diet given to 19 subjects once a month for five days decreased risk factors and biomarkers for aging, diabetes, cardiovascular disease and cancer with no major adverse side effects, according to Longo.”3 (emphasis added)
The FMD is composed primarily of vegetable soups and chamomile tea; participants follow this diet for 5 days a month, and eat normally the rest of the time. On the first day, dieters eat 1,090 calories composed of 10% protein, 56% fat, and 34% carbs. Days 2 through 5 involve just 725 calories and 9% protein, 44 % fat, and 47% carbs.
This Should Sound Very Familiar To Savers
If you have done OsteoCleanse™: the 7-Day Bone Building Accelerator, the FMD will sound familiar. While complete fasting is not a part of the Osteoporosis Reversal Program or OsteoCleanse™, the pH-balanced nutritional plan described in the Program emphasizes fruits and vegetables and is low in animal protein, and the OsteoCleanse™ diet is very similar to the FMD.
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The research is promising – with OsteoCleanse™, you can rejuvenate your bones and enjoy all the incredible health benefits of fasting described above. It’s no wonder that after completing the 7-day OsteoCleanse™, you feel more energetic and focused. Your whole body reaps the benefits!
Please share your thoughts about today’s topics with the community by leaving a comment below.
Till next time,
1 “Following Media Reports of Safety Concerns, Use of Osteoporosis Drugs Down.” Science Codex. June 17, 2015. Web. http://www.sciencecodex.com/following_media_reports_of_safety_concerns_use_of_osteoporosis_drugs_down-159496
2 “Potential breakthrough for osteoporosis announced.” Nursing Times. June 17, 2015. Web. http://www.nursingtimes.net/home/behind-the-headlines/-potential-breakthrough-for-osteoporosis-announced/5086940.article
3 “Diet that mimics fasting appears to slow aging.” Medical Xpress. June 18, 2015. Web. http://medicalxpress.com/news/2015-06-diet-mimics-fasting-aging.html