Save Our Bones Bulletin: Study Identifies Gene That Governs Bone Development; How Thyroid-Stimulating Hormone Impacts Osteoporosis Risk; Meta-Analysis Concludes That Walking Can Extend Your Life - Save Our Bones

This month we’ll explore studies on genes responsible for osteogenesis (bone development), the connection between thyroid function and osteoporosis, and the life-saving benefits of walking.

First, we’ll analyze new research that elucidates how certain bone cell precursors become bone-building cells. This discovery could point toward new therapies for osteoporosis.

Next, we’ll examine a review of studies that delve into the relationship between osteoporosis risk and Thyroid-Stimulating Hormone (TSH), offering new evidence on the limited efficacy of osteoporosis drugs.

Lastly, a comprehensive new study highlights the significant impact of daily walking on life expectancy, a finding that will surely motivate you to lace up your walking shoes.

Study Suggests A New Way To Fight Bone Loss

A new study published in the FASEB journal this past August found that the expression of a particular gene can help prevent bone loss associated with postmenopausal osteoporosis.

The experiment studied laboratory rats to explore how differentiation of precursor cells called bone marrow mesenchymal stem cells (BMSCs) affect bone remodeling. Researchers discovered genes that regulate the osteogenic differentiation of BMSCs. In other words, they identified which genes influence BMSCs to become bone-building cells.

Ultimately, the study authors found a gene called high mobility group AT-hook 1 (Hmga1) that had a positive impact on bone loss.

Relevant Excerpt

“Tests on rats showed an increase in Hmga1 expression during bone creation, but a decrease when the rats underwent ovary removal, simulating the conditions of menopause. Introducing more Hmga1 to these rats led to a notable recovery from bone degradation.
Yihe Hu, PhD, from Zhejiang University in China, the lead author, remarked, “Our study demonstrated that Hmga1 prevents bone loss by promoting the osteogenic differentiation of BMSCs in osteoporosis rats, suggesting that Hmga1 could be an important therapeutic target for osteoporosis.”1

While the study was conducted on rats and not humans, the genetics processes are often similar, though we can't be certain that all findings will directly apply to human biology.

Unfortunately, this intriguing discovery about gene activation in bone remodeling might be primarily directed towards developing new pharmaceutical interventions. If the drug resembles other similar drugs on the market it will use a man-made compound to artificially increase Hmga1 expression– with currently unknown side effects.


In a study on rats, researchers identified a gene called high mobility group AT-hook 1 (Hmga1) that had a positive impact on bone loss. In rats, introducing more Hmga1 prevented bone loss. Pharmaceutical companies are likely to attempt to develop a new drug based on this discovery.

Healthy Thyroid Function Decreases Incidence Of Osteoporosis

A meta-analysis recently published in the journal BMC Women’s Health found that levels of thyroid-stimulating hormone (TSH) in the high end of the normal range were associated with a decreased risk of osteoporosis in postmenopausal women.

The study authors analyzed 19 observational studies that collectively included 23,960 participants. Those studies provided information about participants' TSH levels and bone mass.

TSH is a hormone released by the pituitary gland that controls the thyroid, which in turn produces thyroid hormones. The hormones produced by the thyroid control energy usage and metabolism across all body systems.

Relevant Excerpt

“TSH was positively correlated with bone mineral density, according to the report. After adjusting for confounding factors, which included age, body mass index (BMI), and bone mineral density, multivariate logistic regression revealed individuals with low TSH levels were almost twice as likely to have osteoporosis compared with individuals who had high TSH levels. Additionally, osteoporosis risk remained relatively similar in participants with low TSH who were taking anti osteoporosis drugs compared with individuals who did not use the drugs.”2

This study’s central finding emphasizes the crucial link between thyroid health and bone health. The connectivity of these systems helps explain why a holistic approach to preventing and reversing osteoporosis is more effective than the narrow and harmful approach sold by Big Pharma.

Furthermore, this study found that low TSH levels wiped out any potential benefit of osteoporosis drugs. This data once again further confirms how osteoporosis drugs are ineffective.


A meta-analysis of 19 studies found that participants with thyroid-stimulating hormone (TSH) levels on the high end of the normal range were less likely to be diagnosed with osteoporosis. Additionally, they found that for participants with low TSH levels, there was not a significant difference in bone mass between those who did and did not take osteoporosis drugs. This shows how osteoporosis drugs are ineffective.

Walk Farther To Live Longer

A large meta-analysis published in the European Journal of Preventive Cardiology found that walking at least 3,967 steps a day reduced the risk of dying from any cause and that walking 2,337 steps a day reduced the risk of dying from cardiovascular disease.

These incredible results came from the analysis of 226,889 participants in 17 different studies around the world. In addition to those minimum step counts for attaining baseline benefits, the researchers observed that additional steps conferred more benefits. Participants' risk of dying decreased significantly with each 500 to 1000 extra steps.

An increase of 1000 steps a day was associated with a 15% reduction in the risk of dying from any cause. An increase of 500 steps a day was associated with a 7% reduction in dying from cardiovascular disease. The benefits kept accumulating through the upper limit of steps that the study observed, 20,000 a day.

Relevant Excerpt

”Maciej Banach, Professor of Cardiology at the Medical University of Lodz, says: “In a world where we have more and more advanced drugs to target specific conditions such as cardiovascular disease, I believe we should always emphasize that lifestyle changes, including diet and exercise, which was a main hero of our analysis, might be at least as, or even more effective in reducing cardiovascular risk and prolonging lives. “3

These are powerful words from Professor Banach, and they echo the core principle of the Osteoporosis Reversal Program. Diet, exercise, and lifestyle changes are the most effective tools (and definitely the safest tools) for improving health, building bone, and extending life.

You can act on this discovery immediately by strapping on your walking shoes and heading out for a stroll. As Savers know, walking also benefits your bone health, which no doubt contributes to its power as a life-extender.


A massive meta-analysis of 17 studies found that walking at least 3967 steps a day reduced the risk of dying from any cause and that walking 2337 steps a day reduced the risk of dying from cardiovascular disease. The life extension benefits increased significantly with each additional 500 to 1000 steps that participants took, all the way up to the upper limit the studies considered, 20,000 steps per day.

What This Means To You

Staying healthy and independent requires a healthy diet, consistent exercise, and wise lifestyle decisions. Today’s studies underscore this truth, even as some of them point to new pharmaceutical products in development.

The Osteoporosis Reversal Program makes full use of the most up-to-date research to provide a drug-free path to stronger bones and a fuller, healthier life. As evidenced by today’s studies, nurturing your body with natural health practices, such as regular physical activity, proves more effective than resorting to quick-fix drugs.

In contrast to drugs, diet, exercise, and lifestyle choices typically don’t come with negative side effects. In fact, you’ll find the opposite is true. As your bone health improves, so will your energy, your strength, and your overall well-being.

Keep learning, keep growing stronger, and stay on your all-natural path to a long-lasting and independent future.





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Comments on this article are closed.

  1. Rosemary Hamp

    Hi Vivian! I am writing from Perth in Western Australia where it is very difficult to find natural health practitioners. The doctors here are all very keen on prescribing synthetic medications such as Fosamax etc. My daughter and myself both have high levels of Cortisol and I think her diagnosis will be of Cushing’s Syndrome at her next appt. with the Endocrinologist. The other suggestion was perhaps Barrett’s Esophagus. What do you know about these problems? Is there anything you could recommend which is a holistic way of treating these two ailments. We are both very worried and don’t know where to turn for help.
    Rosemary Hamp.

  2. Terry Williams Kopf

    The comments from the studies about TSH values best to be in the high lab range for better bones strength Can be misleading. When medicating for thyroid function, TSH is normally reduced when supplementation of T3 and T4 is provided to the patient. There is no need for our body to produce thyroid stimulating hormone (TSH) if our Free T3 and Free T4 are in a good normal ranges. Therefore, if medicated properly, our bones should be in good shape

  3. Victoria

    It’s confusing to me how the relative values of TSH are described in the article. As someone who has monitored their TSH levels, my understanding is that high TSH values as derived from lab blood work (outside of the normal reference range) indicate that the thyroid gland is underperforming, and low values indicate that the thyroid is producing the required amount of hormone. Is the conclusion of this study that an underperforming thyroid is associated with increased presence of osteoporosis?

    • Vivian Goldschmidt, MA

      Victoria, a low TSH number indicates an overactive thyroid or hyperthyroidism. As explained in the program, an untreated hyperactive thyroid can lead to excessive bone loss.

      • Terry Williams Kopf

        A low TSH value result can be the result of proper thyroid treatment from the thyroid medication you are taking.

      • Victoria

        Thank you for the clarification. I read the material again and I get the main point.

  4. Janet Ward p/u location #1

    thank you

    • Vivian Goldschmidt, MA

      You’re welcome, Janet!

  5. Connie

    This article about thyroid TSH numbers and osteoporosis has been so beneficial to me. I have felt this way for years. I don’t take osteoporosis meds but I do take thyroid meds. I thought they would fight against each other. I do go for walks daily also. Trying to keep my self healthy naturally if at all possible.

    • Vivian Goldschmidt, MA

      Keep up with your good habits, Connie!

  6. Ita

    Thank you, Ita.

    • Vivian Goldschmidt, MA

      My pleasure, Ita!

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