Scientists Discover Why Stopping Prolia Increases Risk Of Fracture - Save Our Bones

A recently published study has announced the discovery of a new type of bone cell. This groundbreaking research identified a previously unknown type of cell named osteomorphs.

This revelation provides new information about the bone remodeling process and how it interacts with genes that regulate bone growth and quality. It also explains the pernicious side effects of the osteoporosis drug Prolia (denosumab).

Today you'll learn all about osteomorphs and what they elucidate about Prolia's side effects and building strong and healthy bones.

All About Osteomorphs

Osteomorphs are created when osteoclasts have completed their life's work: breaking down old or damaged bone. Previously, scientists thought that when an osteoclast was finished with its task, it was destroyed through the natural cellular process of apoptosis. However, new research has discovered that there is a second possibility for old osteoclasts.

Researchers at the Garvan Institute of Medical Research and the University of New South Wales devised an entirely new technique for observing bone cells within living tissue. This new intravital imaging technique allowed them to watch as some osteoclasts broke down into smaller component cells, now known as osteomorphs.1

These cells have the ability to separate and travel to different locations through bone marrow or blood, and then to recombine to form new osteoclasts. The researchers have named this process osteoclast recycling.

We know that osteomorphs are distinct cells from osteoclasts because of the way they activate genes. Our genes contain specific instructions that our body carries out, but they aren't always activated. The researchers used a cutting-edge single-cell RNA sequencing technology to observe which genes osteomorphs switch on.

Osteomorphs activate several genes that osteoclasts don't affect. That means that osteomorphs are distinct cells that play a previously unknown role in the bone remodeling cycle.1


When osteoclasts are finished resorbing bone, some of them break down into smaller cells called osteomorphs. Osteomorphs can recombine with other osteomorphs to form new osteoclasts. This is called osteoclast recycling. Osteomorphs are different cells than osteoclasts, and they activate different genes.

The Osteoclast Lifecycle

Osteoclast recycling vastly widens our understanding of where osteoclasts come from and what their life cycle is.

Osteoclasts begin their lifecycle through the fusion of monocyte and macrophage precursors. Both monocytes and macrophages are types of white blood cells. Compounds that might have become these cells sometimes become osteoclasts. That happens based on instructions from the signaling system that regulates osteoclast biology and bone resorption. The signaling system is called RANKL (receptor activator of nuclear factor kappa-B ligand).

When osteoclasts' work is done, some of them undergo a process of fission that breaks them down into osteomorphs. Then those osteomorphs can recombine into osteoclasts when the RANKL system signals the need for bone resorption. Clearly, the osteoclast lifecycle is much longer and more complex than previously thought.


Osteoclasts are created from white blood cell precursors. That process is regulated by a signaling system called RANKL. When osteoclasts have completed their bone resorption, some of them break down into osteomorphs. RANKL also regulates the recombination of osteomorphs into new osteoclasts.

Osteomorphs Likely Cause The Increased Risk Of Fractures After Stopping Prolia

This discovery may explain why the osteoporosis drug Prolia (denosumab) can cause bones to weaken and fracture when treatment ends.

Prolia inhibits RANKL, the signaling system that regulates osteoclasts. Until now, we didn't know that RANKL also mediates the recombination of osteomorphs back into osteoclasts.

The researchers postulated that denosumab's RANKL-inhibiting action results in a stockpiling of osteomorphs. Then, when treatment ceases and RANKL is no longer inhibited, all those stored up osteomorphs start rapidly recombining into osteoclasts. This sudden and unnatural rush of osteoclasts resorbs bone at a dangerous rate, resulting in rapid bone loss, frailty, and a higher risk of fracture.1

You might think that this revelation would give the Medical Establishment pause. Suddenly they can see how osteoporosis drugs are meddling with a complex system that is easily thrown off balance by artificial intervention. Unfortunately, they don't see it that way.

Instead, this research is heralded as a direction for developing new drugs. We will keep an eye on how osteomorphs and their role in bone health will be exploited by Big Pharma.


Prolia (denosumab) works by inhibiting RANKL, the signalizing system that regulates osteoclasts. Researchers suggest that osteomorphs build up during treatment with Prolia, and when treatment ends, the return of RANKL triggers a rush of new osteoclasts that weaken bone, leading to an increased risk of fracture. This knowledge, ironically, will likely be used to develop new osteoporosis drugs.

What This Means To You

Instead of using this groundbreaking discovery to fuel Big Pharma's drug production, scientists ought to have observed that the delicate balance of our body responds better to support and care than to chemical tampering.

Until this year, we didn't know exactly why Prolia's intended effect (RANKL inhibition) was causing bone loss, fractures, and suffering when treatment ends — although we could clearly observe that it was. But we did know about the healthy behaviors that are proven to increase bone strength and health. The Osteoporosis Reversal Program was created using those decades of research. New discoveries only reinforce the Program's dependable structure.

Through a pH-balanced diet, regular exercise, and a healthy lifestyle, you can support the natural processes that build strong bones. The more of that complex process we come to understand, the clearer it becomes that a holistic approach to bone health is the best approach.



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Comments on this article are closed.

  1. Agnes murigi

    i was about to take polio in one week time am so glad i read the above testimonies
    thanx again

  2. Sharon

    I was also bullied into taking Prolia. I’ve had 3 injections so far. Is it too late to stop the Prolia? My last bone scans have been bad thanks to hyperparathyroidism which went undiagnosed for 10+ years. Spine -3.2/Hip -4.0. Doctor laughed when I said I wanted to try diet and exercise instead of drugs. Can diet and exercise help me at this point?

    • Save Institute Customer Support

      Sharon, please check your email inbox within the next 24 to 48 hours for an answer to your question. We’re delighted to help you!

      Customer Support

  3. Jan Buchanan

    I was was heading towards osteoporosis very quickly. Bone density tests showed more problems every year.
    I have had Reclast infusions off and on for the last 10 years.
    My bone density has increased exponentially ! No side effects.
    I do not have to have an infusion every year.
    I trust my Rheumatologist !
    I take vitamin K 2 to make my bones more flexible.

    • K

      Yay! Congratulations

  4. Athena Bowler

    Do you recommend taking calcium supplements?

  5. Lisa Mayo

    I’m 51 years old . I just had my first Prolia Injection on 3/2/21, since then I have developed server pain in my left foot, left elbow, shoulder, right hip, growing! My vison is blurry and my neck, jaw and head hurt constantly. I’s scheduled for my second injection in August at this point I think I’m out! I don’t want this in my life, I think I will take my chances with my health.

    • Vivian Goldschmidt, MA

      Lisa, let’s look at the positive side of what’s happening. You only got one dose of Prolia, so it’ll be very easy to mitigate its side effects. With time, they will go away, and I’m quite sure that you’ll pursue a natural protocol to strengthen your bones 🙂

  6. Tish Glenn

    I’ve been exercising with your program, and liking it. I see results! I have been on Prolia for about 3 years. I bought your Osteocleanse to detoxify and stop Prolia. It actually has not helped my osteoporosis much.
    But now I’m afraid to stop it! My Dr. is a pill pusher, so no good advice there. What do you think? I’m 76, healthy, no problems other than bones.

    • Save Institute Customer Support

      Tish, we’d love to help you with your situation, so please check your email inbox within the next 24 to 48 hours 🙂

  7. Joan

    This happened to me! A major university medical center delayed my Prolia shot during a change of medical staff and three vertebrae fractured as a result. This happened over three years ago and the pain is still debilitating. I am sorry I ever agreed to start this horrible drug!

    • Vivian Goldschmidt, MA

      I’m so sorry you’re yet another victim of osteoporosis drugs, Joan, and I hope your condition will improve soon!

  8. Alberta Gittelsohn

    Dear Vivian, I am very interested in your program. After fracturing a vertebrae (L1) in May I went to see an endocrinologist who insists I start Reclast. What is the research on Reclast? I am nervous about the side effects that I know others have had. She claimed none of her patients had side effects. Also, naturopathic doctor recommended strontium citrate. Do you have any information on that? Thanks so much,
    Alberta Gittelsohn

  9. Connie S Townsend

    Hi Vivian,
    Can you reverse this effect that Prolia has. My last Prolia injection was April 15th 2020. Does that mean I’m going to suffer a fracture? The Dr. that I was seeing for my osteoporosis was a bully and dismissed all my complaints about the side effects that I was having. She told me that if I stopped that I would have a fracture. I decided despite her bulling that I was going to take things into my own hands. I have been on your diet and exercise program since last October. I had a benign thyroid nodule and since I’ve been on this diet, it’s shrinking. Please advice.

    • Vivian Goldschmidt, MA

      Congratulations, Connie! You’re on the right track, so keep up with the Program and your exercise routine and let go of the fear. Remember, osteoporosis is not a disease, and now you’re strengthening your bones without drugs 🙂

  10. maggie

    Good information and research.

    • Vivian Goldschmidt, MA

      I’m glad you’ve enjoyed today’s article, Maggie 🙂

  11. gene

    In Italy people are using DiBase 25,000 IU every 2 wks .

  12. Marlene

    Hello Vivian,
    Thank you for sharing valuable and helpful information
    regarding Prolia.

    Have a wonderful day.

    • Vivian Goldschmidt, MA

      You’re very welcome, Marlene!

  13. Joy Markman

    What can I say about you VIvian, you are unbelievable as far as “Save our bones” goes – I wish the doctor’s would read up on your research, & take note!

    Thank you so much from Cape Town, South Africa.

    • Vivian Goldschmidt, MA

      I thank you for your kind words, Joy, and you’re very welcome 🙂

  14. Ruby

    You mentioned Polio weakens the bones when stopped but what happened if one doesn’t stop. My 97 year old mother has osteoporosis switched to Polio four years ago and her last scan showed that her bone density has not decreased. I look forward to your response.

    • Vivian Goldschmidt, MA

      Ruby, studies have shown that when treatment with Prolia is discontinued, bone resorption (which is blocked by the drug) rapidly picks back up and reaches twice its normal rate within a year of the last injection. So stopping the drug treatment results in a drastic drop in bone mineral density (BMD) and an increase in fracture risk.

      Aside from that, Prolia is a drug that does more than altering the bone remodeling process; it also affects the immune system. You can read about it here:

  15. Ronald Brown

    Coming up to 85 years of age. Recently fell over in the snow and landed on my hands with no injuries. A few years ago, walked across lawn in the dark and hit a bird feeder with my knee, so hard, it moved 2 feet away. Again no damage, just a slight graze on the knee. Put this down to being brought up in the war years with restricted food, but also fed good varied meals. Very active in my youth and even in my 40 s did a lot of fast walking in London to meet my wife at her working place. I believe that you bone strength is down to these years and eating porridge. My parents families did not suffer bone problems. My height is almost the same as it was at 18

    • Vivian Goldschmidt, MA

      Thanks for sharing your story with our community, Ronald!

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